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Figure 2.
Fig. 2. Interaction of IF1 with the 30S subunit. (A) Close-up
of the IF1 binding site, with IF1 in purple, helix 44 in cyan,
the 530 loop in green, and protein S12 in orange. These colors
are used throughout Figs. 2 and 3. (B) Overview showing the
position of IF1 (purple) with respect to the 30S subunit (gray).
H44, 530 loop, and S12 are colored as in (A). H, head; Bo, body;
N, neck; Sh, shoulder; P, platform. (C) Overview of the 30S
showing helix 44, S12, and the 530 loop as in (A), but with the
A- P- and E-site tRNAs modeled as described in the text, in dark
blue, orange, and yellow, respectively. Comparison with (B)
shows that IF1 would block the binding of A-site tRNA. (D)
Stereo pair showing A1492 and A1493 in H44 buried into protein
pockets formed by IF1 and a combination of IF1 and S12.
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