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Figure 2.
Figure 2. Schematic conformations of various
oligonucleotides. (a), HNA (1′-3′-dideoxy (4′→6′)
oligonucleotides), (b) RNA (ribose (5′→3′
oligonucleotides)), (c) hexopyranosyl (4′→6′)
oligonucleotide and (d) pentopyranosyl (2′→4′)
oligonucleotides. The resemblance between the hexitol ring and
the ribose can be seen by inserting a CH[2] group between the
O4′ and C1′ of the ribose. This is indicated by the dashed
line in the schematic RNA structure (b). Homo DNA is a chemical
analogue of (c), i.e. containing 2′-3′-dideoxy hexopyranosyl
(4′-6′) nucleotides.
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