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Figure 2.
Figure 2. ROO is a modular enzyme. a, The ROO dimer (monomers
in blue and brown), showing the  -lactamase-like
(light) and flavodoxin-like (dark) domains, iron (orange
spheres) and FMN (stick model). A two-fold axis relates both
monomers. b, The -lactamase-like
domain. Left, a ribbon diagram with termini labeled. Right,
stereo view of the -lactamase-like
domain (blue) superimposed on -lactamases
from Stenotrophomonas maltophilia^11 (green), Bacillus cereus12
(deep pink) and Bacteroides fragilis13 (gold). Additional ROO
structural elements in the region corresponding to the substrate
groove of -lactamases
are indicated in dark blue. c, The flavodoxin-like domain. Left,
ribbon diagram. Right, stereo view of the flavodoxin-like domain
(blue) superimposed on Desulfovibrio vulgaris 32 (brown) and
Clostridium beijerinckii17 (violet) flavodoxins.
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