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Figure 1.
Fig. 1. Sequence alignment of cathepsin L and SERA5E. (a)
Structural alignment^29 of SERA5E with the enzyme domain of
cathepsin L (CatL; PDB 1mhw). Secondary-structure elements
(helices and strands, cylinders and arrows, respectively) in
SERA5E are indicated. Lowercase font refers to structurally
unaligned regions. (b) Secondary-structure topology of SERA5E,
showing disulfide bonding between cysteine residues; disulfide
bonds unique to SERA5E are asterisked (1–2* between C567 and
C572, 3–5* between C581 and C610). Black circles indicate the
relative disposition of the triad of catalytic residues S596,
H762, and N787.
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