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Figure 1.
Structures of individual compounds leading to the discovery
of PLX4720 are shown. (A) The chemical structure of
3-aminophenyl-7-azaindole (compound 1) is shown beneath its
costructure with Pim-1 kinase. (B) The chemical structure of
3-(3-methoxybenzyl)-7-azaindole (compound 2) is shown beneath
its costructure with the kinase domain of FGFR1. (C) The
chemical structure of PLX4720 is shown beneath its costructure
with B-Raf kinase.
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