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Figure 1.
Figure 1. Structure of the RABEX-5 HB-VPS9 tandem in complex
with nucleotide-free RAB21. (a) Ribbon representation. The
catalytic core of RABEX-5 consists of a helical bundle (light
brown;  HB1–
HB4),
a VPS9 domain (brown; V1–
V6)
and a C-terminal helix (dark brown; C).
RAB21 ( 1–
5
and  1–
6)
is depicted in gray with the P-loop, switch and interswitch
regions colored as indicated. (b) Docking of nonpolar residues
in the switch and interswitch regions of Rab21 in the
hydrophobic groove between the V4
and V6
helices of the VPS9 domain. RABEX-5 is depicted as a gray ribbon
with yellow side chains underneath a semitransparent surface.
RAB21 is depicted as a tube with side chains. (c) Network of
intermolecular polar interactions at the RAB21–VPS9 domain
interface. Dotted lines represent hydrogen bonds.
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