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Figure 1.
Heterogeneity in the αV–αVII regions of R12 subfamily RGS
domains versus the canonical RGS domain fold of R4, R7, and RZ
subfamily members. (A) Apo-RGS domains of R4 subfamily member
RGS8 (green; PDB ID 2IHD), R7 subfamily member RGS9 (orange; PDB
ID 1FQI), and RZ subfamily member RGS19 (gray; PDB ID 1CMZ) were
aligned along helices αIV and αV and superimposed by using
PyMOL. (B–D) Apo-RGS domains of RGS14 (B) (blue; PDB ID 2JNU),
RGS10 from this study (C) (salmon; PDB ID 2I59), and RGS10 from
Yokoyama et al. (D) (light purple; PDB ID 2DLR) are presented to
highlight differences in the αV–αVI–αVII region. The
heterogeneous αVI regions are specifically highlighted in cyan
(B), red (C), and magenta (D), respectively.
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