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Figure 1.
FIGURE 1. Overall fold and surface representation of the
CTD of FANCF. a, the protein fold of the CTD of the FANCF
fragment consists of 10  -helices. Helices 2- 9 form
four hairpins (HP1-HP4) flanked on the N and C termini by helix
1
(purple) and 10 (red), respectively.
Loop L1, connecting helix 1 and 2 of
hairpin HP1 and loop L2, connecting helix 3 of HP1 with helix
4
of hairpin HP2 are disordered in the crystals. b, full-length
human FANCF (gray bar) is a 374-residue polypeptide. The
crystallized fragment includes residues 156-357 (green bar). A
region of high sequence conservation (Leu-329-Leu-352, orange)
is expanded to show alignment between four species (Fr, Fugu
rubripes; Xl, Xenopus laevis; Mm, Mus musculus; and Hs, Homo
sapiens). c, surface representations of FANCF CTD showing the
location of the Leu-329-Leu-352 conserved region (orange).
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