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Figure 1.
Figure 1. A, Domain structure of spinophilin (top) and neurabin
(bottom). Sequence identity between the domains is annotated in
the figure. B, Primary sequence alignment of the neurabin SAM
and shank3 SAM domains. The zinc binding residues in shank3 and
the corresponding residues in neurabin are highlighted by boxes
(see text). The shank3 (M1803E) mutation that is necessary to
achieve high enough protein solubility and reduced aggregation
is underlined. Secondary structure for the neurabin SAM domain
is included above the sequence alignment.
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