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Figure 1.
Figure 1 The catalytic cycle of the HlyB-NBD. Crystal structures
of the monomeric nucleotide-free (Schmitt et al, 2003), dimeric
ATP-bound (H662A and E631Q) and monomeric ADP-bound (wild type,
E631Q and H662A) forms (this study) are shown. For simplicity,
the structure of the ATP/Mg^2+-bound form (Zaitseva et al,
2005a) is not shown. The catalytic domain is colored in light
yellow and the helical domain in light tan. Conserved motifs are
highlighted and color-coded as follows: Walker A (residues
502–510, blue), Q-loop (residues 549–556, brown),
ABC-signature motif (residues 606–610, red), Pro-loop
(residues 623–625, orange), Walker B (residues 626–630,
magenta), D-loop (residues 634–637, black) and H-loop
(residues 661–663, green). Bound ligands are shown in
ball-and-stick representation. K[D] values were taken from
Zaitseva et al (2005b).
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