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Figure 1.
Fig. 1. Structure of FMDV 3D catalytic complexes. Molecular
surface of the polymerase (gray) is shown, with the position of
the rNTP substrates and the trajectory of RNA template–primer
and duplex product in two different complexes: the
3D·GCAUGGGCCC·ATP/UTP (A) and the
3D·GCAUGGGCCC-RTP (B). The N-terminal residues (residues
34–48) and residues at the top of the NTP tunnel (163–180)
of 3D are omitted to show the substrate cavities. RNA molecules
are shown in yellow (template strands) and green (primer
strands). (A) The UTP substrate is shown in cyan. (B) The
position of the antiviral mutagen RTP is shown in orange. Metal
ions are shown as red spheres.
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