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Figure 1.
Figure 1. Chemical transformation resulting from
antibody-catalyzed prodrug activation and chemical formulae of
the compounds used in this study. Antibodies 6D9 and 9C10 were
raised against chloramphenicol phosphonate 3 and catalyze the
hydrolysis of chloramphenicol ester 1 to generate
chloramphenicol 2 and the acid product. Sub-Lys (4) was used for
the ITC study.
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