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Figure 1.
FIGURE 1. Solution structure of the Smurf2 WW3 domain-Smad7
PY peptide complex. a, superposition of the 30 lowest energy
structures. The WW3 domain backbone is shown in blue and side
chains in turquoise, except for positions typically occupied by
conserved Trp residues, which are in green. The PY peptide
backbone is red with side chains shown in gold. b, ribbon
diagram of the lowest energy structure. The coloring scheme is
as in a, except that WW3 domain loop regions are shown in gray.
Residues designated with a prime symbol (') are Smad7 residues.
For clarity, some side chains are not shown. Figs. 1, 2, 3a, and
5b were generated using MOLMOL (37). N, N terminus; C, C
terminus.
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