Figure 1.
FIGURE 1. Crystal structure of the LILRA5 extracellular
domain. A, ribbon drawing of the structure of LILRA5 in a
rainbow color scheme from blue (N-terminal) to red (C-terminal).
The dotted lines represent the disordered residues of loop
regions (residues 106-116 and 136-138). The star indicates the
predicted N-linked glycosylation site. B, topological diagram of
LILRA5 structure. The arrows show the direction of the -strands.
Cylinders labeled PP show polyproline II-type helices. C, left,
overall view of domain 2 of LILRA5 (magenta) superimposed on
LILRB1 (yellow). The region between 106 and 116 is disordered.
Right, close-up view of the box in the left panel. LILRA5 and
LILRB1 are shown in magenta and yellow stick models,
respectively. Hydrogen bonds made between A' and G strands are
shown in green dashed lines. The green dotted circle indicates
the residue 105 following the disordered loop of LILRA5. The
black dotted circle indicates the C-terminal residue of LILRA5
unable to form the A'GFCC' -sheet due to the
distortion caused by Pro^194 (see text).
-strands.
Cylinders labeled PP show polyproline II-type helices. C, left,
overall view of domain 2 of LILRA5 (magenta) superimposed on
LILRB1 (yellow). The region between 106 and 116 is disordered.
Right, close-up view of the box in the left panel. LILRA5 and
LILRB1 are shown in magenta and yellow stick models,
respectively. Hydrogen bonds made between A' and G strands are
shown in green dashed lines. The green dotted circle indicates
the residue 105 following the disordered loop of LILRA5. The
black dotted circle indicates the C-terminal residue of LILRA5
unable to form the A'GFCC'