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Figure 1.
Figure 1: Structure of Epac2. a, Domain organization of Epac.
The same colour code is used throughout the figures. CDC25-HD,
CDC25-homology domain; cNBD, cyclic-nucleotide-binding domain;
DEP, Dishevelled, Egl-10, Pleckstrin domain; RA, Ras-association
domain; REM, Ras-exchange motif. b, Ribbon diagram of Epac2 in
stereo view. Missing connectivity is indicated by coloured
dotted lines. The green ball indicates the cAMP-binding site in
cNBD-B. HP, helical hairpin of the CDC25-HD (dark blue); SB,
switchboard; IL, ionic latch (doted black lines); CH, connecting
helix (helix H4 in ref 13). c, Surface representation of Epac.
d, Superposition of Epac and the Ras-Sos complex. The RA, DEP
and REM domains are omitted. Only Ras (magenta) from the Ras-Sos
complex is shown.
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