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Figure 1.
Figure 1. Mouse CD8aa complex with the YTS 105.18 Fab. (a)
Ribbon diagram of the refined model of the CD8aa/YTS 105.18 Fab
complex. Fab1 and Fab2 are in green and blue, respectively. The
CD8a1 and CD8a2 subunits are in maroon. (b) The epitope for the
YTS 105.18 Fab on the surface of the CD8aa subunit. YTS 105.18
binds the A, A' and B strands of CD8a. The epitope molecular
surface (grey) covered by YTS 105.18 is superimposed on the
ribbon diagram of CD8aa. Arg8 and Glu6 of CD8a, which are
involved in hydrogen bonding to class I pMHC, TL and also to YTS
105.18 Fab, are indicated. The single N-glycosylation site at
Asn42 within the CD8 construct is also indicated.
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