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Figure 1.
Figure 1. Scheme of the modular organization of members of the
LDLR family. LDLR and VLDLR have seven and eight N-terminal
ligand binding repeats, L1 -L7 and V1 -V8, respectively. Three
epidermal growth factor precursor-like regions (A -C) flank a
six-bladed  -propeller
( )
with YWTD motifs. The adjacent domain (GLYCO) carries O-linked
oligosaccharides. The receptors are anchored in the membrane via
a single transmembrane domain (TM). The intracellular C termini
carry NPXY clathrin-localization signals.
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