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Figure 1.
Figure 1. Overall structures of ITSN -Cdc42 and Dbs -RhoA. a,
Stereo view of an electron density map calculated using
density-modified MAD experimental phases contoured at 1.2  and
displayed with the refined  6
helix of the DH domain of ITSN. b, Stereo view of a
representative portion of the 2F[o]-F[c] electron density of the
Dbs -RhoA structure, contoured at 1.3 and
displayed with residues 759 -772 of Dbs (yellow) and residues 54
-62 of RhoA (green). c, Ribbon diagram of the ITSN -Cdc42
structure. The DH domain is yellow, and the PH domain is blue,
with defined secondary structural elements labeled in accordance
with described nomenclature^8. Cdc42 is green, except for the
switch regions (s1 = residues 26 -40 and s2 = residues 57 -76),
which are red. d, Ribbon diagram of the Dbs -RhoA complex.
Coloring and labeling are equivalent to the ITSN -Cdc42
structure. All figures were prepared using SPOCK
(http://quorum.tamu.edu/jon/spock/) or MOLSCRIPT36.
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