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Figure 1.
Figure 1 General structure and domain organization of TdT. (A)
Linear arrangement of the different domains of C-TdT (blue),
compared with pol  .
The two motifs C and A and the two HhH consensus sequences are
indicated in red and green, respectively. The disordered part of
C-TdT in the crystal is in cyan and the N-terminal extension of
C-TdT compared with pol is
in magenta. The part of the molecule absent from the
crystallized construct is in white. (B) General architecture of
the TdT structure drawn with Molscript (Kraulis, 1991). The
three catalytic aspartate residues are shown in ball-and-stick
representation. The N- and C-termini are in dark blue, while the
two strictly conserved stretches of sequences implicated in the
binding of the incoming dNTP are in cyan and magenta. Loop1 is
shown in yellow. An intrinsic magnesium ion (grey) as well as
the two putative sodium ions bound to the HhH motifs are
represented in CPK mode (blue); only the Na^+ ion with ligands
in an octahedral geometry is labelled.
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