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Figure 1.
Figure 1. Structure of the U2AF^35/U2AF^65 Complex(A)
Stereoview of the U2AF^65 proline-rich loop enveloping U2AF^35
Trp134. Density modified, experimental electron density map for
residues Trp92p to Pro104p of U2AF^65 contoured at 1σ. The
U2AF^65 peptide is shown in pink, or color coded for atom type
(yellow, carbon; red, oxygen; and blue, nitrogen) and the
U2AF^35 domain is shown in light blue. Six disordered amino
acids linking α helix A with the RNP2 β strand 1 are
represented with a dashed line. The RNP motifs and α helices A
and B are labeled.(B) The U2AF complex viewed along the
cylindrical axis of α helix A. A schematic representation of
the reciprocal tryptophan binding sites is shown on the left.(C)
View of the binary complex perpendicular to the perspective of
(B).(D) U2AF^35 β sheet that forms the RNA binding surfaces of
canonical RRM-containing proteins
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