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Figure 1.
Figure 1 (A) The modular architecture of human FN showing the
type I, II and III repeats and the known binding sites for
various ligands. Boxes in green and blue correspond to regions
where structural information is available (Williams et al.,
1994; Leahy et al., 1996; Sticht et al., 1998). (B) A
structure-based sequence alignment of 17 type III human FN
repeats. Secondary structure classification is based on all
repeats in FN12–14; FNEDA and FNEDB denotes the extra repeats
A and B. Residues in green are identical in all 17 repeats, in
aquamarine are identical in at least 12 repeats, and in yellow
identical in 8–11 repeats. Residues in red are implicated in
integrin binding. The first nine residues of FN15 (shaded) are
part of IIICS (see text). All molecular graphic figures are
generated using BOBSCRIPT (Esnouf, 1997) and RASTER3D (Merritt
and Murphy, 1994), or GRASP (Nicholls et al., 1991).
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