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Figure 1.
Figure 1. Decarboxylation of 5-nitro-3-carboxybenzisoxazole
2 proceeds through a charge-delocalized transition state 3 to
give salicylonitrile 4. Naphthalene disulfonate 1 was used to
elicit the decarboxylase antibody 21D8 through a covalent
linkage to keyhole limpet hemocyanin (KLH).
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