Figure 1 - full size

Figure 1.
Fig. 1. The chemical structure of the p56^lck SH2 domain inhibitor used in the current study. The inhibitor contains a cmF residue as a replacement for the pY residue. The cmFEEI inhibitor is about 450-fold less potent than the pYEEI inhibitor (pH 7.4) in the binding of the SH2 domain.