DescriptionNeighbouring genes, particularly on bacterial genomes, are often functionally related. Thus a functionally characterized neighbour may provide some clue to a query protein's role. Where the query protein's own genome has not been determined, or is not informative, the functional information can sometimes come from the genome of a homologous relative.
The genome location search takes the top 10 UniProt sequences matched by the BLAST run and tries to locate the genes in the corresponding genomes. Where found, functional information, including Genome Ontology classification, is extracted from the UniProt files, where available.
The summary page shows which of the homologues matched by BLAST have genome loaction data. Those that do will have a "house" icon in the leftmost column. Clicking on this icon will open a new page showing the gene's location in its genome and listing its neighbours and any functional annotation found for them.