_EC 6.4.1.3 Propionyl-CoA carboxylase. 10 PDB entries  
EC 6.-.-.- Ligases. [1,591 PDB entries]
EC 6.4.-.- Forming carbon-carbon bonds. [95 PDB entries]
EC 6.4.1.- Ligases that form carbon-carbon bonds. [95 PDB entries]
EC 6.4.1.3 Propionyl-CoA carboxylase. [10 PDB entries]    
1vrg

Reaction: Atp + propanoyl-CoA + HCO(3)(-) = adp + phosphate + (S)-methylmalonyl- CoA.
 


ATP
+
propanoyl-CoA
+
HCO(3)(-)
=
ADP
+
phosphate
+
(S)-methylmalonyl- CoA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): PCCase.
Cofactor(s): Biotin.
 

Biotin
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Also carboxylates butanoyl-CoA and catalyzes transcarboxylation.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 10 PDB entries in enzyme class E.C.6.4.1.3

  PDB code Protein
1vrg
Crystal structure of propionyl-coa carboxylase, beta subunit from thermotoga maritima at 2.30 a resolution
Source: Thermotoga maritima. Organism_taxid: 243274. Strain: msb8. Gene: tm0716. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (515 residues) CATH domains: 3.90.226.10 3.90.226.10
1x0u
Crystal structure of the carboxyl transferase subunit of put of sulfolobus tokodaii
Source: Sulfolobus tokodaii. Organism_taxid: 273063. Strain: 7. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (518 residues) CATH domains: 3.90.226.10 3.90.226.10
2a7s
Crystal structure of the acyl-coa carboxylase, accd5, from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: accd5, pccb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (529 residues) CATH domains: 3.90.226.10 3.90.226.10
2bzr
Crystal structure of accd5 (rv3280), an acyl-coa carboxylase beta-subunit from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (512 residues) CATH domains: 3.90.226.10 3.90.226.10
2cqy
Solution structure of b domain from human propionyl-coa carboxylase alpha subunit
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pcca. Other_details: cell free protein synthesis
Chain: A (108 residues) CATH domain: 3.30.1490.20
2jku
Crystal structure of the n-terminal region of the biotin acceptor domain of human propionyl-coa carboxylase
Source: Homo sapiens. Human. Organism_taxid: 9606. Organelle: mitochondria. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.
Chain: A (35 residues)
3n6r
Crystal structure of the holoenzyme of propionyl-coa carboxy
Source: Ruegeria pomeroyi. Organism_taxid: 89184. Gene: pcca, spo1101. Expressed in: escherichia coli. Expression_system_taxid: 562. Roseobacter denitrificans. Organism_taxid: 375451. Strain: och 114. Gene: pccb, rd1_2028.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (591 residues) CATH domains: 3.40.50.20 3.30.470.20 Unassigned 2.40.50.100
Bound ligand:   Het Group BTI is 93.75% similar to enzyme cofactor Biotin
4fb8
Crystal structure of apo acyl-coa carboxylase
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: accd6, mt2307, mtcy427.28, rv2247. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (435 residues) CATH domains: 3.90.226.10 3.90.226.10
4g2r
Crystal structure of the carboxyltransferase subunit of acc complex with inhibitor haloxyfop from mycobacterium tubercu
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: accd6, mt2307, mtcy427.28, rv2247. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (440 residues) CATH domains: 3.90.226.10 3.90.226.10
4l6w
Carboxyltransferase subunit (accd6) of mycobacterium tubercu acetyl-coa carboxylase
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: accd6, mt2307, mtcy427.28, rv2247. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (412 residues) CATH domains: 3.90.226.10 3.90.226.10