_EC 6.3.5.3 Phosphoribosylformylglycinamidine synthase. 8 PDB entries  
EC 6.-.-.- Ligases. [633 PDB entries]
EC 6.3.-.- Forming carbon-nitrogen bonds. [307 PDB entries]
EC 6.3.5.- Carbon--nitrogen ligases with glutamine as amido-N-donor. [29 PDB entries]
EC 6.3.5.3 Phosphoribosylformylglycinamidine synthase. [8 PDB entries]    
1twj

Pathway: Purine Biosynthesis (early stages)
Reaction: Atp + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O = Adp + phosphate + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine + L-glutamate.
 


ATP
+
N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
+
L-glutamine
+ H(2)O
=
ADP
+
phosphate
+
2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine
+
L-glutamate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Fgam synthase. Fgam synthetase. Fgar amidotransferase. Fgarat. Formylglycinamide ribotide amidotransferase. Phosphoribosylformylglycinamidine synthetase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 8 PDB entries in enzyme class E.C.6.3.5.3

  PDB code Protein
1twj
Crystal structure of b. Subtilis purs p21 crystal form
Source: Bacillus subtilis. Organism_taxid: 1423. Gene: yexa, bsu06460. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (80 residues) CATH domain: 3.30.1280.10
1vq3
Crystal structure of phosphoribosylformylglycinamidine synth subunit (ec 6.3.5.3) (tm1244) from thermotoga maritima at 1 resolution
Source: Thermotoga maritima. Organism_taxid: 243274. Strain: msb8. Gene: tm1244. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (86 residues) CATH domain: 3.30.1280.10
2hru
T. Maritima purl complexed with adp
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: purl. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (581 residues) CATH domains: 3.90.650.10 3.30.1330.10 3.30.1330.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2hs3
T. Maritima purl complexed with fgar
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: purl. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (602 residues) CATH domains: 3.90.650.10 3.30.1330.10 3.30.1330.10
Bound ligands:   Het Group FGR corresponds to enzyme reactant N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
  Het Group PO4 corresponds to enzyme product phosphate
2hs4
T. Maritima purl complexed with fgar and amppcp
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: purl. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (602 residues) CATH domains: 3.90.650.10 3.30.1330.10 3.30.1330.10
Bound ligands:   Het Group FGR corresponds to enzyme reactant N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
  Het Group ACP is 81.00% similar to enzyme product ADP
  Het Group PO4 corresponds to enzyme product phosphate
3ac6
Crystal structure of purl from thermus thermophilus
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: purl, ttha1519. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (703 residues) CATH domains: 3.90.650.10 3.30.1330.10 3.30.1330.10 3.90.650.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
3viu
Crystal structure of purl from thermus thermophilus
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: purl, ttha1519. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (703 residues) CATH domains: 3.90.650.10 3.30.1330.10 3.30.1330.10 3.90.650.10
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group PO4 corresponds to enzyme product phosphate
4mgh
Importance of hydrophobic cavities in allosteric regulation formylglycinamide synthetase: insight from xenon trapping a statistical coupling analysis
Source: Salmonella typhimurium. Organism_taxid: 99287. Strain: lt2 / sgsc1412 / atcc 700720. Gene: purl, stm2565. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (1284 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned
Bound ligands:   Het Group ACT is 40.00% similar to enzyme reactant L-glutamine
  Het Group ADP corresponds to enzyme product ADP