_EC 6.3.4.5 Argininosuccinate synthase. 14 PDB entries  
EC 6.-.-.- Ligases. [1,591 PDB entries]
EC 6.3.-.- Forming carbon-nitrogen bonds. [803 PDB entries]
EC 6.3.4.- Other carbon--nitrogen ligases. [240 PDB entries]
EC 6.3.4.5 Argininosuccinate synthase. [14 PDB entries]    
1j1z

Pathway: Urea Cycle and Arginine Biosynthesis
Reaction: Atp + L-citrulline + L-aspartate = amp + diphosphate + N(omega)- (L-arginino)succinate.
 


ATP
+
L-citrulline
+
L-aspartate
=
AMP
+
diphosphate
+ N(omega)- (L-arginino)succinate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Arginine succinate synthetase. Argininosuccinate synthetase. Citrulline--aspartate ligase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 14 PDB entries in enzyme class E.C.6.3.4.5

  PDB code Protein
1j1z
Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with substrate
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (386 residues) CATH domains: 3.40.50.620 3.90.1260.10
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group CIR corresponds to enzyme reactant citrulline
  Het Group ASP corresponds to enzyme reactant L-aspartate
1j20
Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with product
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (386 residues) CATH domains: 3.40.50.620 3.90.1260.10
Bound ligands:   Het Group AS1 is 52.00% similar to enzyme reactant citrulline
  Het Group AMP corresponds to enzyme product AMP
1j21
Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with atp and citrulline
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (380 residues) CATH domains: 3.40.50.620 3.90.1260.10
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group CIR corresponds to enzyme reactant citrulline
1k92
Crystal structure of uncomplexed e. Coli argininosuccinate s
Source: Escherichia coli. Organism_taxid: 562. Gene: argg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (444 residues) CATH domains: 3.40.50.620 3.90.1260.10 1.10.287.400
1k97
Crystal structure of e. Coli argininosuccinate synthetase in with aspartate and citrulline
Source: Escherichia coli. Organism_taxid: 562. Gene: argg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (432 residues) CATH domains: 3.40.50.620 3.90.1260.10 1.10.287.400
Bound ligands:   Het Group CIR corresponds to enzyme reactant citrulline
  Het Group ASP corresponds to enzyme reactant L-aspartate
1kh1
Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (380 residues) CATH domains: 3.40.50.620 3.90.1260.10
1kh2
Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with atp
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (380 residues) CATH domains: 3.40.50.620 3.90.1260.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1kh3
Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with inhibitor
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (380 residues) CATH domains: 3.40.50.620 3.90.1260.10
Bound ligands:   Het Group ARG is 84.00% similar to enzyme reactant citrulline
  Het Group ASP corresponds to enzyme reactant L-aspartate
  Het Group ANP is 74.00% similar to enzyme product AMP
1kor
Crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with inhibitors
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (380 residues) CATH domains: 3.40.50.620 3.90.1260.10 1.20.5.470
Bound ligands:   Het Group ARG is 84.00% similar to enzyme reactant citrulline
  Het Group SIN is 88.00% similar to enzyme reactant L-aspartate
  Het Group ANP is 74.00% similar to enzyme product AMP
1kp2
Crystal structure of e. Coli argininosuccinate synthetase in with atp
Source: Escherichia coli. Organism_taxid: 562. Gene: argg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (431 residues) CATH domains: 3.40.50.620 3.90.1260.10 1.10.287.400
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group PO4 is 55.56% similar to enzyme product diphosphate
1kp3
Crystal structure of e. Coli argininosuccinate synthetase in with atp and citrulline
Source: Escherichia coli. Organism_taxid: 562. Gene: argg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (439 residues) CATH domains: 3.40.50.620 3.90.1260.10 1.10.287.400
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group CIR corresponds to enzyme reactant citrulline
  Het Group PO4 is 55.56% similar to enzyme product diphosphate
1vl2
Crystal structure of argininosuccinate synthase (tm1780) fro thermotoga maritima at 1.65 a resolution
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: argg, tm1780. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (398 residues) CATH domains: 3.40.50.620 3.90.1260.10 1.20.5.470
2nz2
Crystal structure of human argininosuccinate synthase in com aspartate and citrulline
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ass1, ass. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (402 residues) CATH domains: 3.40.50.620 3.90.1260.10 1.20.5.470
Bound ligands:   Het Group CIR corresponds to enzyme reactant citrulline
  Het Group ASP corresponds to enzyme reactant L-aspartate
4nzp
The crystal structure of argininosuccinate synthase from cam jejuni subsp. Jejuni nctc 11168
Source: Campylobacter jejuni subsp. Jejuni. Organism_taxid: 192222. Strain: nctc 11168. Gene: argg, campylobacter jejuni, cj0665c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (385 residues) CATH domains: 3.40.50.620 3.90.1260.10