_EC 6.3.4.13 Phosphoribosylamine--glycine ligase. 30 PDB entries  
EC 6.-.-.- Ligases. [1,568 PDB entries]
EC 6.3.-.- Forming carbon-nitrogen bonds. [793 PDB entries]
EC 6.3.4.- Other carbon--nitrogen ligases. [240 PDB entries]
EC 6.3.4.13 Phosphoribosylamine--glycine ligase. [30 PDB entries]    
1gso

Pathway: Purine Biosynthesis (early stages)
Reaction: Atp + 5-phospho-D-ribosylamine + glycine = adp + phosphate + N(1)- (5-phospho-D-ribosyl)glycinamide.
 


ATP
+
5-phospho-D-ribosylamine
+
glycine
=
ADP
+
phosphate
+
N(1)- (5-phospho-D-ribosyl)glycinamide
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Gar synthetase. Gars. Glycinamide ribonucleotide synthetase. Phosphoribosylglycinamide synthetase.
Comments: Formerly Ec 6.3.1.3.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 30 PDB entries in enzyme class E.C.6.3.4.13

  PDB code Protein
1gso
Glycinamide ribonucleotide synthetase (gar-syn) from e. Coli.
Source: Escherichia coli. Organism_taxid: 562. Strain: tx635. Cell_line: b834(de3)
Chain: A (419 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
1mej
Human glycinamide ribonucleotide transformylase domain at ph
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A, C (201 residues) CATH domain: 3.40.50.170
Bound ligands:   Het Group GOL is 42.86% similar to enzyme reactant 5-phospho-beta-D-ribosylamine
  Het Group PO4 corresponds to enzyme product phosphate
1men
Complex structure of human gar tfase and substrate beta-gar
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (201 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group GAR corresponds to enzyme product N(1)-(5-phospho-D-ribosyl)glycinamide
1meo
Human glycinamide ribonucleotide transformylase at ph 4.2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (202 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group PO4 corresponds to enzyme product phosphate
1njs
Human gar tfase in complex with hydrolyzed form of 10- trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8- tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (200 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group PO4 corresponds to enzyme product phosphate
1rbm
Human gar tfase complex structure with polyglutamated 10- (trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8- tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (200 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group PO4 corresponds to enzyme product phosphate
1rbq
Human gar tfase complex structure with 10-(trifluoroacetyl)- 5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (200 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group PO4 corresponds to enzyme product phosphate
1rby
Human gar tfase complex structure with 10-(trifluoroacetyl)- 5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid and substrate beta-gar
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (200 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group GAR corresponds to enzyme product N(1)-(5-phospho-D-ribosyl)glycinamide
1rbz
Human gar tfase complex structure with polyglutamated 10- (trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8- tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (200 residues) CATH domain: 3.40.50.170
1rc0
Human gar tfase complex structure with polyglutamated 10- (trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8- tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (200 residues) CATH domain: 3.40.50.170
1rc1
Human gar tfase complex structure with polyglutamated 10- (trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8- tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (200 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group PO4 corresponds to enzyme product phosphate
1vkz
Crystal structure of phosphoribosylamine--glycine ligase (tm thermotoga maritima at 2.30 a resolution
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: purd, tm1250. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (391 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligand:   Het Group EDO is 50.00% similar to enzyme reactant Glycine
1zlx
The apo structure of human glycinamide ribonucleotide transf
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, prgs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (200 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group GOL is 42.86% similar to enzyme reactant 5-phospho-beta-D-ribosylamine
1zly
The structure of human glycinamide ribonucleotide transformylase in complex with alpha,beta-n- (hydroxyacetyl)-d-ribofuranosylamine and 10-formyl-5,8, dideazafolate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, prgs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (200 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group GRF corresponds to enzyme reactant 5-phospho-beta-D-ribosylamine
2ip4
Crystal structure of glycinamide ribonucleotide synthetase f thermus thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: ttha0811. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (414 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
2qk4
Human glycinamide ribonucleotide synthetase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, pgft, prgs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (420 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2v9y
Human aminoimidazole ribonucleotide synthetase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (314 residues) CATH domains: 3.30.1330.10 3.90.650.10
2xcl
Nucleotide-bound structures of bacillus subtilis glycinamide ribonucleotide synthetase
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (422 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
2xd4
Nucleotide-bound structures of bacillus subtilis glycinamide ribonucleotide synthetase
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (422 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2yrw
Crystal structure of gar synthetase from geobacillus kaustop
Source: Geobacillus kaustophilus. Organism_taxid: 1462. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (413 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligand:   Het Group PO4 corresponds to enzyme product phosphate
2yrx
Crystal structure of gar synthetase from geobacillus kaustop
Source: Geobacillus kaustophilus. Organism_taxid: 1462. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (420 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligands:   Het Group AMP is 85.00% similar to enzyme product ADP
  Het Group PO4 corresponds to enzyme product phosphate
2ys6
Crystal structure of gar synthetase from geobacillus kaustop
Source: Geobacillus kaustophilus. Organism_taxid: 1462. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (421 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligands:   Het Group GLY corresponds to enzyme reactant Glycine
  Het Group AMP is 85.00% similar to enzyme product ADP
2ys7
Crystal structure of gar synthetase from geobacillus kaustop
Source: Geobacillus kaustophilus. Organism_taxid: 1462. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (413 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
2yw2
Crystal structure of gar synthetase from aquifex aeolicus in with atp
Source: Aquifex aeolicus. Organism_taxid: 63363. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (423 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group PO4 corresponds to enzyme product phosphate
2yya
Crystal structure of gar synthetase from aquifex aeolicus
Source: Aquifex aeolicus. Organism_taxid: 63363. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (423 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
3lp8
Crystal structure of phosphoribosylamine-glycine ligase from ehrlichia chaffeensis
Source: Ehrlichia chaffeensis. Organism_taxid: 205920. Strain: arkansas. Gene: purd, ech_1006. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (421 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligand:   Het Group PO4 corresponds to enzyme product phosphate
3mjf
Phosphoribosylamine-glycine ligase from yersinia pestis
Source: Yersinia pestis. Organism_taxid: 214092. Strain: co92. Gene: purd, y0501, ypo3729, yp_3092. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (429 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligands:   Het Group PGE is 41.00% similar to enzyme reactant 5-phospho-beta-D-ribosylamine
  Het Group EDO is 50.00% similar to enzyme reactant Glycine
4ew1
High resolution structure of human glycinamide ribonucleotid transformylase in apo form.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, pgft, prgs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (205 residues) CATH domain: 3.40.50.170
4ew2
The structure of human glycinamide ribonucleotide transformy complex with 10s-methylthio-ddathf.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, pgft, prgs. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (205 residues) CATH domain: 3.40.50.170
4ew3
The structure of human glycinamide ribonucleotide transformy complex with 10r-methylthio-ddathf.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, pgft, prgs. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (205 residues) CATH domain: 3.40.50.170