_EC 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase. 8 PDB entries  
EC 6.-.-.- Ligases. [1,578 PDB entries]
EC 6.3.-.- Forming carbon-nitrogen bonds. [794 PDB entries]
EC 6.3.3.- Cyclo-ligases. [71 PDB entries]
EC 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase. [8 PDB entries]    
1sbq

Pathway: Folate Coenzymes
Reaction: Atp + 5-formyltetrahydrofolate = adp + phosphate + 5,10- methenyltetrahydrofolate.
 


ATP
+
5-formyltetrahydrofolate
=
ADP
+
phosphate
+
5,10- methenyltetrahydrofolate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 5,10-methenyltetrahydrofolate synthetase. 5-Formyltetrahydrofolate cyclodehydrase. Methenyl-THF synthetase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 8 PDB entries in enzyme class E.C.6.3.3.2

  PDB code Protein
1sbq
Crystal structure of methenyltetrahydrofolate synthetase from mycoplasma pneumoniae at 2.2 resolution
Source: Mycoplasma pneumoniae. Organism_taxid: 2104. Gene: mpn348, mp488. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (164 residues) CATH domain: 3.40.50.10420
1u3f
Structural and functional characterization of a 5,10- methenyltetrahydrofolate synthetase from mycoplasma pneumoniae (gi: 13508087)
Source: Mycoplasma pneumoniae. Organism_taxid: 2104. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (164 residues) CATH domain: 3.40.50.10420
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group PO4 corresponds to enzyme product phosphate
1u3g
Structural and functional characterization of a 5,10- methenyltetrahydrofolate synthetase from mycoplasma pneumoniae (gi: 13508087)
Source: Mycoplasma pneumoniae. Organism_taxid: 2104. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (164 residues) CATH domain: 3.40.50.10420
Bound ligands:   Het Group THF corresponds to enzyme reactant 5-formyltetrahydrofolate
  Het Group ADP corresponds to enzyme product ADP
  Het Group PO4 corresponds to enzyme product phosphate
2jcb
The crystal structure of 5-formyl-tetrahydrofolate cycloligase from bacillus anthracis (ba4489)
Source: Bacillus anthracis. Organism_taxid: 198094. Strain: ames. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: plyss.
Chains: A, B (194 residues) CATH domain: 3.40.50.10420
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group PO4 corresponds to enzyme product phosphate
3hxt
Structure of human mthfs
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mthfs. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (195 residues) CATH domain: 3.40.50.10420
3hy3
Structure of human mthfs with 10-formyltetrahydrofolate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mthfs. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (196 residues) CATH domain: 3.40.50.10420
Bound ligand:   Het Group 10F is 97.06% similar to enzyme product 5,10-
3hy4
Structure of human mthfs with n5-iminium phosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mthfs. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (195 residues) CATH domain: 3.40.50.10420
Bound ligands:   Het Group N5G corresponds to enzyme reactant 5-formyltetrahydrofolate
  Het Group PO4 is 80.00% similar to enzyme product phosphate
3hy6
Structure of human mthfs with adp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mthfs. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (198 residues) CATH domain: 3.40.50.10420
Bound ligand:   Het Group PO4 corresponds to enzyme product phosphate