_EC 6.3.2.9 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase. 22 PDB entries  
EC 6.-.-.- Ligases. [1,580 PDB entries]
EC 6.3.-.- Forming carbon-nitrogen bonds. [793 PDB entries]
EC 6.3.2.- Acid--amino-acid ligases (peptide synthases). [329 PDB entries]
EC 6.3.2.9 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase. [22 PDB entries]    
1e0d

Pathway: Peptidoglycan Biosynthesis (Part 1)
Reaction: Atp + UDP-N-acetylmuramoyl-L-alanine + glutamate = adp + phosphate + UDP- N-acetylmuramoyl-L-alanyl-D-glutamate.
 


ATP
+
UDP-N-acetylmuramoyl-L-alanine
+
glutamate
=
ADP
+
phosphate
+
UDP- N-acetylmuramoyl-L-alanyl-D-glutamate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): D-glutamate ligase. D-glutamate-adding enzyme. MurD synthetase. UDP-Mur-NAC-L-Ala:D-Glu ligase. UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase. UDP-N-acetylmuramoylalanine--D-glutamate ligase. Uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase.
Comments: Involved with Ec 6.3.2.4, Ec 6.3.2.7 or Ec 6.3.2.13, Ec 6.3.2.8 and Ec 6.3.2.10 in the synthesis of a cell-wall peptide.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 22 PDB entries in enzyme class E.C.6.3.2.9

  PDB code Protein
1e0d
Udp-n-acetylmuramoyl-l-alanine:d-glutamate ligase
Source: Escherichia coli. Organism_taxid: 562. Strain: jm83 (pmld58)urce. Gene: murd gene. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (429 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
1eeh
Udp-n-acetylmuramoyl-l-alanine:d-glutamate ligase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (431 residues) CATH domains: 3.40.50.720 3.90.190.20 3.40.1190.10
Bound ligand:   Het Group UMA corresponds to enzyme reactant UDP-N- acetylmuramoyl-L-alanine
1uag
Udp-n-acetylmuramoyl-l-alanine:d-glutamate ligase
Source: Escherichia coli. Organism_taxid: 562. Cell_line: jm83. Gene: murd gene. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (428 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
Bound ligand:   Het Group UMA corresponds to enzyme reactant UDP-N- acetylmuramoyl-L-alanine
2jff
Crystal structure of murd ligase in complex with d-glu containing sulfonamide inhibitor
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: dh5a.
Chain: A (433 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2jfg
Crystal structure of murd ligase in complex with uma and adp
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: dh5a.
Chain: A (440 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
Bound ligands:   Het Group UMA corresponds to enzyme reactant UDP-N- acetylmuramoyl-L-alanine
  Het Group ADP corresponds to enzyme product ADP
2jfh
Crystal structure of murd ligase in complex with l-glu containing sulfonamide inhibitor
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: dh5a.
Chain: A (431 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2uag
Udp-n-acetylmuramoyl-l-alanine:d-glutamate ligase
Source: Escherichia coli. Organism_taxid: 562. Strain: jm83 (pmld58). Gene: murd gene. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (429 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
Bound ligands:   Het Group UMA corresponds to enzyme reactant UDP-N- acetylmuramoyl-L-alanine
  Het Group ADP corresponds to enzyme product ADP
2uuo
Crystal structure of murd ligase in complex with d-glu containing sulfonamide inhibitor
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: dh5a.
Chain: A (430 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2uup
Crystal structure of murd ligase in complex with d-glu containing sulfonamide inhibitor
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: dh5a.
Chain: A (440 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2vtd
Crystal structure of murd ligase in complex with d-glu containing sulfonamide inhibitor
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: dh5a.
Chain: A (435 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2vte
Crystal structure of murd ligase in complex with d-glu containing sulfonamide inhibitor
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: dh5a.
Chain: A (434 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2wjp
Crystal structure of murd ligase in complex with d-glu conta rhodanine inhibitor
Source: Escherichia coli dh5[alpha]. Organism_taxid: 668369. Expressed in: escherichia coli dh5[alpha]. Expression_system_taxid: 668369.
Chain: A (435 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2x5o
Discovery of novel 5-benzylidenerhodanine- and 5-benzylidene thiazolidine-2,4-dione inhibitors of murd ligase
Source: Escherichia coli. Organism_taxid: 668369. Strain: dh5[alpha]. Expressed in: escherichia coli. Expression_system_taxid: 668369. Expression_system_cell_line: dh5[alpha].
Chain: A (439 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2xpc
Second-generation sulfonamide inhibitors of murd: activity optimisation with conformationally rigid analogues of d- glutamic acid
Source: Escherichia coli. Organism_taxid: 562. Cell_line: dh5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (435 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2y1o
Dual-target inhibitor of murd and mure ligases: design, synthesis and binding mode studies
Source: Escherichia coli. Organism_taxid: 668369. Strain: dh5[alpha]. Expressed in: escherichia coli. Expression_system_taxid: 668369.
Chain: A (435 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2y66
New 5-benzylidenethiazolidine-4-one inhibitors of bacterial murd ligase: design, synthesis, crystal structures, and biological evaluation
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Expressed in: escherichia coli. Expression_system_taxid: 668369.
Chain: A (434 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2y67
New 5-benzylidenethiazolidine-4-one inhibitors of bacterial murd ligase: design, synthesis, crystal structures, and biological evaluation
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Expressed in: escherichia coli. Expression_system_taxid: 668369.
Chain: A (435 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
2y68
Structure-based design of a new series of d-glutamic acid- based inhibitors of bacterial murd ligase
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (435 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
3lk7
The crystal structure of udp-n-acetylmuramoylalanine-d- glutamate (murd) ligase from streptococcus agalactiae to 1.5a
Source: Streptococcus agalactiae. Organism_taxid: 216466. Strain: 2603v, serogroup v. Gene: murd, sag0475. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (448 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
3uag
Udp-n-acetylmuramoyl-l-alanine:d-glutamate ligase
Source: Escherichia coli. Organism_taxid: 562. Strain: jm83 (pmld58). Gene: murd gene. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (430 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
Bound ligands:   Het Group UMA corresponds to enzyme reactant UDP-N- acetylmuramoyl-L-alanine
  Het Group ADP corresponds to enzyme product ADP
4buc
Crystal structure of murd ligase from thermotoga maritima in
Source: Thermotoga maritima. Organism_taxid: 2336. Strain: dsm 3109. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (427 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
Bound ligand:   Het Group PO4 corresponds to enzyme product phosphate
4uag
Udp-n-acetylmuramoyl-l-alanine:d-glutamate ligase
Source: Escherichia coli. Organism_taxid: 562. Strain: jm83 (pmld58). Gene: murd gene. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (429 residues) CATH domains: 3.40.50.720 3.40.1190.10 3.90.190.20
Bound ligand:   Het Group UAG corresponds to enzyme product UDP-N-acetylmuramoyl-L-alanyl-D-glutamate