_EC 6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase. 3 PDB entries  
EC 6.-.-.- Ligases. [1,591 PDB entries]
EC 6.3.-.- Forming carbon-nitrogen bonds. [803 PDB entries]
EC 6.3.2.- Acid--amino-acid ligases (peptide synthases). [339 PDB entries]
EC 6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase. [3 PDB entries]    
4bub

Pathway: Peptidoglycan Biosynthesis (Part 1)
Reaction: Atp + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine = adp + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine.
 


ATP
+
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
+
L-lysine
=
ADP
+
phosphate
+
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): L-lysine-adding enzyme. MurE synthetase. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase. UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase. Uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase.
Comments: Involved with Ec 6.3.2.4, Ec 6.3.2.8, Ec 6.3.2.9 and Ec 6.3.2.10 in the synthesis of a cell-wall peptide. This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms Ec 6.3.2.13 adds 2,6-diaminopimelate instead.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 3 PDB entries in enzyme class E.C.6.3.2.7

  PDB code Protein
4bub
Crystal structure of mure ligase from thermotoga maritima in complex with adp
Source: Thermotoga maritima. Organism_taxid: 2336. Strain: dsm 3109. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (478 residues) CATH domains: 3.40.1390.10 3.40.1190.10
4c12
X-ray crystal structure of staphylococcus aureus mure with udp-murnac-ala-glu-lys and adp
Source: Staphylococcus aureus. Organism_taxid: 1280. Strain: 8325. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chain: A (493 residues) CATH domains: 3.40.1390.10 3.40.1190.10 3.90.190.20
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group UML corresponds to enzyme product UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine
4c13
X-ray crystal structure of staphylococcus aureus mure with udp-murnac-ala-glu-lys
Source: Staphylococcus aureus. Organism_taxid: 1280. Strain: 8325. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chain: A (490 residues) CATH domains: 3.40.1390.10 3.40.1190.10 3.90.190.20
Bound ligands:   Het Group PO4 corresponds to enzyme product phosphate
  Het Group UML corresponds to enzyme product UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine