_EC 6.3.2.6 Phosphoribosylaminoimidazolesuccinocarboxamide synthase. 19 PDB entries  
EC 6.-.-.- Ligases. [1,591 PDB entries]
EC 6.3.-.- Forming carbon-nitrogen bonds. [803 PDB entries]
EC 6.3.2.- Acid--amino-acid ligases (peptide synthases). [339 PDB entries]
EC 6.3.2.6 Phosphoribosylaminoimidazolesuccinocarboxamide synthase. [19 PDB entries]    
1a48

Pathway: Purine Biosynthesis (late stages)
Reaction: Atp + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = Adp + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate.
 


ATP
+
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
+
L-aspartate
=
ADP
+
phosphate
+ (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase. 4-(N-succinocarboxamide)-5-aminoimidazole synthetase. 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase. Phosphoribosylaminoimidazole-succinocarboxamide synthase. Phosphoribosylaminoimidazole-succinocarboxamide synthetase. Phosphoribosylaminoimidazolesuccinocarboxamide synthetase. Saicar synthase. Saicar synthetase. Saicars.
Comments: Forms part of the purine biosynthesis pathway.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 19 PDB entries in enzyme class E.C.6.3.2.6

  PDB code Protein
1a48
Saicar synthase
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: grf18
Chain: A (299 residues) CATH domains: 3.30.200.20 3.30.470.20
1kut
Structural genomics, protein tm1243, (saicar synthetase)
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm1243. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (213 residues) CATH domains: 3.30.200.20 3.30.470.20
1obd
Saicar-synthase complexed with atp
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Chain: A (299 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1obg
Saicar-synthase complexed with atp
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Chain: A (305 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligand:   Het Group AMP is 85.00% similar to enzyme product ADP
2cnq
Atomic resolution structure of saicar-synthase from saccharomyces cerevisiae complexed with adp, aicar, succinate
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Chain: A (302 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligands:   Het Group AMZ is 91.00% similar to enzyme reactant 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
  Het Group SIN is 88.00% similar to enzyme reactant L-aspartate
  Het Group ADP corresponds to enzyme product ADP
2cnu
Atomic resolution structure of saicar-synthase from saccharomyces cerevisiae complexed with aspartic acid
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Chain: A (303 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligand:   Het Group ASP corresponds to enzyme reactant L-aspartate
2cnv
Saicar-synthase from saccharomyces cerevisiae complexed saicar
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Chain: A (300 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligands:   Het Group SSS is 67.00% similar to enzyme reactant 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
  Het Group ASP corresponds to enzyme reactant L-aspartate
2gqr
Saicar synthetase complexed with adp-mg2+
Source: Escherichia coli. Organism_taxid: 562. Gene: purc. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (237 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2gqs
Saicar synthetase complexed with cair-mg2+ and adp
Source: Escherichia coli. Organism_taxid: 562. Gene: purc. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (237 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligands:   Het Group C2R corresponds to enzyme reactant 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
  Het Group ADP corresponds to enzyme product ADP
2h31
Crystal structure of human paics, a bifunctional carboxylase synthetase in purine biosynthesis
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: paics, ade2, airc, pais. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (386 residues) CATH domains: Unassigned 3.40.50.7700
2ywv
Crystal structure of saicar synthetase from geobacillus kaus
Source: Geobacillus kaustophilus. Organism_taxid: 1462. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (237 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2yzl
Crystal structure of phosphoribosylaminoimidazole- succinocarboxamide synthase with adp from methanocaldococcus jannaschii
Source: Methanocaldococcus jannaschii. Organism_taxid: 2190. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (238 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2z02
Crystal structure of phosphoribosylaminoimidazolesuccinocarboxamide synthase wit atp from methanocaldococcus jannaschii
Source: Methanocaldococcus jannaschii. Organism_taxid: 2190. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (242 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group CIT is 57.00% similar to enzyme reactant L-aspartate
3kre
Crystal structure of phosphoribosylaminoimidazole-succinocar synthase from ehrlichia chaffeensis at 1.8a resolution
Source: Ehrlichia chaffeensis str. Arkansas. Organism_taxid: 205920. Strain: arkansas. Gene: purc, ech_0290. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (237 residues) CATH domains: 3.30.200.20 3.30.470.20
3nua
Crystal structure of phosphoribosylaminoimidazole-succinocar synthase from clostridium perfringens
Source: Clostridium perfringens. Organism_taxid: 195103. Strain: atcc 13124. Gene: cpf_0673, purc. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (236 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligands:   Het Group CIT is 57.14% similar to enzyme reactant L-aspartate
  Het Group ADP corresponds to enzyme product ADP
3r9r
Structure of a phosphoribosylaminoimidazole-succinocarboxami synthase from mycobacterium abscessus atcc 19977 / dsm 4419
Source: Mycobacterium abscessus. Organism_taxid: 561007. Strain: atcc 19977 / dsm 44196. Gene: purc, mab_0689. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (295 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligand:   Het Group MRD is 41.67% similar to enzyme reactant L-aspartate
3u54
Crystal structure (type-1) of saicar synthetase from pyrococ horikoshii ot3
Source: Pyrococcus horikoshii. Organism_taxid: 70601. Strain: ot3. Gene: ph0239, purc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (225 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligand:   Het Group BU1 is 66.67% similar to enzyme reactant L-aspartate
3u55
Crystal structure (type-2) of saicar synthetase from pyrococ horikoshii ot3
Source: Pyrococcus horikoshii. Organism_taxid: 70601. Strain: ot3. Gene: ph0239, purc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (227 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligand:   Het Group ACT is 44.44% similar to enzyme reactant L-aspartate
4fe2
X-ray structure of saicar synthetase (purc) from streptococc pneumoniae complexed with air, adp, asp and mg2+
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Gene: purc, sp_0044. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (233 residues) CATH domains: 3.30.200.20 3.30.470.20
Bound ligands:   Het Group ASP corresponds to enzyme reactant L-aspartate
  Het Group ADP corresponds to enzyme product ADP