_EC 6.3.2.3 Glutathione synthase. 14 PDB entries  
EC 6.-.-.- Ligases. [1,619 PDB entries]
EC 6.3.-.- Forming carbon-nitrogen bonds. [819 PDB entries]
EC 6.3.2.- Acid--amino-acid ligases (peptide synthases). [340 PDB entries]
EC 6.3.2.3 Glutathione synthase. [14 PDB entries]    
1glv

Reaction: Atp + gamma-L-glutamyl-L-cysteine + glycine = adp + phosphate + glutathione.
 


ATP
+
gamma-L-glutamyl-L-cysteine
+
glycine
=
ADP
+
phosphate
+
glutathione
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Glutathione synthetase. Gsh synthetase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 14 PDB entries in enzyme class E.C.6.3.2.3

  PDB code Protein
1glv
Three-dimensional structure of the glutathione synthetase from escherichia coli b at 2.0 angstroms resolution
Source: Escherichia coli. Organism_taxid: 562
Chain: A (299 residues) CATH domains: 3.40.50.20 3.30.470.20 3.30.1490.20
1gsa
Structure of glutathione synthetase complexed with adp and g
Source: Escherichia coli. Organism_taxid: 37762. Strain: b. Expressed in: escherichia coli. Expression_system_taxid: 562. 3.
Chain: A (314 residues) CATH domains: 3.40.50.20 3.30.470.20 3.30.1490.20
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group GSH corresponds to enzyme product glutathione
1gsh
Structure of escherichia coli glutathione synthetase at ph 7
Source: Escherichia coli. Organism_taxid: 37762. Strain: b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (296 residues) CATH domains: 3.40.50.20 3.30.470.20 3.30.1490.20
1lp5
Theoretical model of glutathione synthetase
Source: Salmonella typhi. Bacteria
Chain: A (315 residues)
1m0t
Yeast glutathione synthase
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gsh2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (454 residues) CATH domains: 3.30.1490.80 3.30.470.20 1.10.1080.10 3.40.50.1760 3.30.1490.50
1m0w
Yeast glutathione synthase bound to gamma-glutamyl-cysteine, amp-pnp and 2 magnesium ions
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gsh2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (481 residues) CATH domains: 3.30.1490.80 3.30.470.20 1.10.1080.10 3.40.50.1760 3.30.1490.50
Bound ligands:   Het Group 3GC corresponds to enzyme reactant gamma-glutamylcysteine
  Het Group ANP is 81.00% similar to enzyme product ADP
2glt
Structure of escherichia coli glutathione synthetase at ph 6
Source: Escherichia coli. Organism_taxid: 37762. Strain: b. Gene: gshii.
Chain: A (296 residues) CATH domains: 3.40.50.20 3.30.470.20 3.30.1490.20
2hgs
Human glutathione synthetase
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: brain. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: cdna
Chain: A (472 residues) CATH domains: 3.30.1490.80 3.30.470.20 1.10.1080.10 3.40.50.1760 3.30.1490.50
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group GSH corresponds to enzyme product glutathione
2wyo
Trypanosoma brucei glutathione synthetase
Source: Trypanosoma brucei. Organism_taxid: 5691. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta plyss.
Chains: A, B, C, D (520 residues) CATH domains: Unassigned Unassigned Unassigned 3.40.50.1760
Bound ligand:   Het Group GSH corresponds to enzyme product glutathione
3kaj
Apoenzyme structure of homoglutathione synthetase from glycine max in open conformation
Source: Glycine max. Soybeans. Organism_taxid: 3847. Gene: hgs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (452 residues) CATH domains: 3.30.1490.80 3.30.470.20 1.10.1080.10 3.40.50.1760
3kak
Structure of homoglutathione synthetase from glycine max in open conformation with gamma-glutamyl-cysteine bound.
Source: Glycine max. Soybeans. Organism_taxid: 3847. Gene: hgs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (443 residues) CATH domains: 3.30.1490.80 3.30.470.20 1.10.1080.10 3.40.50.1760
Bound ligand:   Het Group 3GC corresponds to enzyme reactant gamma-glutamylcysteine
3kal
Structure of homoglutathione synthetase from glycine max in closed conformation with homoglutathione, adp, a sulfate ion, and three magnesium ions bound
Source: Glycine max. Organism_taxid: 3847. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (470 residues) CATH domains: 3.30.1490.80 3.30.470.20 1.10.1080.10 3.40.50.1760 3.30.1490.50
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group HGS is 78.00% similar to enzyme product glutathione
3ln6
Crystal structure of a bifunctional glutathione synthetase f streptococcus agalactiae
Source: Streptococcus agalactiae serogroup v. Organism_taxid: 216466. Strain: baa-811. Gene: gshab, gshf, sag1821. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (743 residues) CATH domains: Unassigned Unassigned
3ln7
Crystal structure of a bifunctional glutathione synthetase f pasteurella multocida
Source: Pasteurella multocida. Organism_taxid: 747. Gene: gshab, gshf, pm1048. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (747 residues) CATH domains: Unassigned Unassigned