_EC 6.3.2.25 Tubulin--tyrosine ligase. 0 PDB entries  
EC 6.-.-.- Ligases. [1,381 PDB entries]
EC 6.3.-.- Forming carbon-nitrogen bonds. [705 PDB entries]
EC 6.3.2.- Acid--amino-acid ligases (peptide synthases). [291 PDB entries]
EC 6.3.2.25 Tubulin--tyrosine ligase. [-]    

Reaction: Atp + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + adp + phosphate.
 


ATP
+
detyrosinated alpha-tubulin
+
L-tyrosine
=
alpha-tubulin
+
ADP
+
phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Ttl.
Comments: L-tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyr(omega)-alpha-tubulin). The enzyme is highly specific for alpha-tubulin and moderately specific for Atp and L-tyrosine. L-phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.6.3.2.25