_EC 6.3.2.19 Ubiquitin--protein ligase. 120 PDB entries  
EC 6.-.-.- Ligases. [1,580 PDB entries]
EC 6.3.-.- Forming carbon-nitrogen bonds. [793 PDB entries]
EC 6.3.2.- Acid--amino-acid ligases (peptide synthases). [329 PDB entries]
EC 6.3.2.19 Ubiquitin--protein ligase. [120 PDB entries]    
1ayz

Reaction: Atp + ubiquitin + protein lysine = amp + diphosphate + protein N-ubiquityllysine.
 


ATP
+ ubiquitin
+
protein lysine
=
AMP
+
diphosphate
+ protein N-ubiquityllysine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Ubiquitin-activating enzyme. Ubiquitin-conjugating enzyme.
Comments: Ubiquitin is coupled to protein by a peptide bond between the C-terminal glycine of ubiquitin and epsilon-amino groups of lysine residues in the protein. An intermediate in the reaction contains one ubiquitin residue bound as a thioester to the enzyme, and a residue of ubiquitin adenylate non-covalently bound to the enzyme.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 120 PDB entries in enzyme class E.C.6.3.2.19

  PDB code Protein
1ayz
Crystal structure of the saccharomyces cerevisiae ubiquitin- conjugating enzyme rad6 (ubc2) at 2.6a resolution
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Chains: A, B, C (153 residues) CATH domain: 3.10.110.10
1c4z
Structure of e6ap: insights into ubiquitination pathway
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: D (144 residues) CATH domain: 3.10.110.10
1e2c
Destruction of mitotic cyclins
Source: Spisula solidissima. Atlantic surf clam
Chains: A, B, C (156 residues) CATH domain: 3.10.110.10
1fbv
Structure of a cbl-ubch7 complex: ring domain function in ubiquitin-protein ligases
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized. Expression_system_taxid: 562
Chain: C (144 residues) CATH domain: 3.10.110.10
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein lysine
1fxt
Structure of a conjugating enzyme-ubiquitin thiolester complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
Chain: A (149 residues) CATH domain: 3.10.110.10
1fzy
Crystal structure of saccharomyces cerevisiae ubiquitin conjugating enzyme 1
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (149 residues) CATH domain: 3.10.110.10
1i7k
Crystal structure of human mitotic-specific ubiquitin- conjugating enzyme, ubch10
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ubch10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (146 residues) CATH domain: 3.10.110.10
1j7d
Crystal structure of hmms2-hubc13
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: B (149 residues) CATH domain: 3.10.110.10
1jas
Hsubc2b
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (152 residues) CATH domain: 3.10.110.10
1jat
Mms2/ubc13 ubiquitin conjugating enzyme complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ubc13. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mms2.
Chain: A (152 residues) CATH domain: 3.10.110.10
1jbb
Ubiquitin conjugating enzyme, ubc13
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ubc13. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: gst-fusion
Chains: A, B (148 residues) CATH domain: 3.10.110.10
1nxa
Homology modeled ubiquitin-protein ligase b
Source: Homo sapiens. Human
Chain: A (152 residues)
1pzv
Crystal structures of two ubc (e2) enzymes of the ubiquitin- conjugating system in caenorhabditis elegans
Source: Caenorhabditis elegans. Organism_taxid: 6239. Gene: f58a4.10. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (152 residues) CATH domain: 3.10.110.10
1q34
Crystal structures of two ubc (e2) enzymes of the ubiquitin- conjugating system in caenorhabditis elegans
Source: Caenorhabditis elegans. Organism_taxid: 6239. Gene: ubc-1 or c35b1.1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (149 residues) CATH domain: 3.10.110.10
1qcq
Ubiquitin conjugating enzyme
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Chain: A (148 residues) CATH domain: 3.10.110.10
1tte
The structure of a class ii ubiquitin-conjugating enzyme, ubc1.
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ubc1, ydr177w, yd9395.10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (215 residues) CATH domains: 3.10.110.10 1.10.8.10
1ur6
Nmr based structural model of the ubch5b-cnot4 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chain: A (147 residues)
1w4u
Nmr solution structure of the ubiquitin conjugating enzyme ubch5b
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (147 residues) CATH domain: 3.10.110.10
1wzv
Crystal structure of ubch8
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (150 residues) CATH domain: 3.10.110.10
1wzw
Crystal structure of ubch8
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (150 residues) CATH domain: 3.10.110.10
1x23
Crystal structure of ubch5c
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (153 residues) CATH domain: 3.10.110.10
1y6l
Human ubiquitin conjugating enzyme e2e2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2e2, ubch8. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (148 residues) CATH domain: 3.10.110.10
1yf9
Structural analysis of leishmania major ubiquitin conjugatin e2
Source: Leishmania major. Organism_taxid: 5664. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: t7 system
Chains: A, B, C (158 residues) CATH domain: 3.10.110.10
1yh2
Ubiquitin-conjugating enzyme hspc150
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hspc150. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (156 residues) CATH domain: 3.10.110.10
1yh6
Human ubiquitin-conjugating enzyme e2 h
Source: Homo sapiens. Human. Gene: ube2h. Expressed in: escherichia coli.
Chains: A, B (152 residues) CATH domain: 3.10.110.10
1yla
Ubiquitin-conjugating enzyme e2-25 kda (huntington interacti 2)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hip2, lig. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (201 residues) CATH domains: 3.10.110.10 1.10.8.10
1yrv
Novel ubiquitin-conjugating enzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mgc35130. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: the n-terminal cloning tag mgsshhhhhhssglvpr not been removed from the protein
Chain: A (153 residues) CATH domain: 3.10.110.10
1z2u
The 1.1a crystallographic structure of ubiquitin- conjugating enzyme (ubc-2) from caenorhabditis elegans: functional and evolutionary significance
Source: Caenorhabditis elegans. Organism_taxid: 6239. Gene: ubc-2, let-70. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (150 residues) CATH domain: 3.10.110.10
1z3d
Protein crystal growth improvement leading to the 2.5a crystallographic structure of ubiquitin-conjugating enzyme (ubc-1) from caenorhabditis elegans
Source: Caenorhabditis elegans. Organism_taxid: 6239. Gene: ubc-1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (151 residues) CATH domain: 3.10.110.10
1z5q
Nmr based structural model of the sumo-3/ubc9 complex
Source: Homo sapiens. Human. Human
Chain: A (159 residues)
1zdn
Ubiquitin-conjugating enzyme e2s
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2s, e2epf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (151 residues) CATH domain: 3.10.110.10
1zuo
Structure of human ubiquitin-conjugating enzyme (ubci) invol embryo attachment and implantation
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: loc92912. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (162 residues) CATH domain: 3.10.110.10
2a7l
Structure of the human hypothetical ubiquitin-conjugating en loc55284
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flj11011. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (123 residues) CATH domain: 3.10.110.10
2aak
Ubiquitin conjugating enzyme from arabidopsis thaliana
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (150 residues) CATH domain: 3.10.110.10
2awf
Structure of human ubiquitin-conjugating enzyme e2 g1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2g1, ube2g. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (122 residues) CATH domain: 3.10.110.10
2ayv
Crystal structure of a putative ubiquitin-conjugating enzyme toxoplasma gondii
Source: Toxoplasma gondii. Organism_taxid: 5811. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (148 residues) CATH domain: 3.10.110.10
2b9g
In silico analysis identifies a novel c3hc4 ring finger domain of an e3 ubiquitin-protein ligase located at thE C- terminus of a polyglutamine-containing protein (aj277365, af525300, ay879229)
Source: Homo sapiens. Human
Chain: A (64 residues)
2bep
Crystal structure of ubiquitin conjugating enzyme e2-25k
Source: Bos taurus. Bovine. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (156 residues) CATH domain: 3.10.110.10
2bf8
Crystal structure of sumo modified ubiquitin conjugating enzyme e2-25k
Source: Bos taurus. Bovine. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.
Chain: A (154 residues) CATH domain: 3.10.110.10
2c2v
Crystal structure of the chip-ubc13-uev1a complex
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chains: B, E, H, K (152 residues) CATH domain: 3.10.110.10
2c4o
Crystal structure of human ubiquitin-conjugating enzyme ubch5b
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chains: A, B, C, D (150 residues) CATH domain: 3.10.110.10
2c4p
Crystal structure of human ubiquitin-conjugating enzyme ubch5a
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chains: A, B (150 residues) CATH domain: 3.10.110.10
2clw
Crystal structure of human ubiquitin-conjugating enzyme ubch
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chains: A, B, C, D (150 residues) CATH domain: 3.10.110.10
2cyx
Structure of human ubiquitin-conjugating enzyme e2 g2 (ube2g2/ubc7)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2g2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (169 residues) CATH domain: 3.10.110.10
2e2c
E2-c, an ubiquitin conjugating enzyme required for the destr mitotic cyclins
Source: Spisula solidissima. Atlantic surf clam. Organism_taxid: 6584
Chain: A (156 residues) CATH domain: 3.10.110.10
2esk
Human ubiquitin-conjugating enzyme (e2) ubch5b, wild-type
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d2, ubc4, ubch5b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (149 residues) CATH domain: 3.10.110.10
2eso
Human ubiquitin-conjugating enzyme (e2) ubch5b mutant ile37a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d2, ubc4, ubch5b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (149 residues) CATH domain: 3.10.110.10
2esp
Human ubiquitin-conjugating enzyme (e2) ubch5b mutant ile88a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d2, ubc4, ubch5b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (149 residues) CATH domain: 3.10.110.10
2esq
Human ubiquitin-conjugating enzyme (e2) ubch5b mutant ser94g
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d2, ubc4, ubch5b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (149 residues) CATH domain: 3.10.110.10
2f4w
Human ubiquitin-conjugating enzyme e2 j2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2j2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (147 residues) CATH domain: 3.10.110.10
2fuh
Solution structure of the ubch5c/ub non-covalent complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d3, ubch5c. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Rattus norvegicus. Norway rat. Organism_taxid: 10116.
Chain: A (146 residues) CATH domain: 3.10.110.10
2gmi
Mms2/ubc13~ubiquitin
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ubc13. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mms2. Homo sapiens. Human.
Chain: A (152 residues) CATH domain: 3.10.110.10
2kjh
Nmr based structural model of the ubch8-ubiquitin complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2l6, ubch8. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rps27a uba80, ubcep1, uba52, ubb, ubc.
Chain: A (150 residues) CATH domain: 3.10.110.10
2kly
Solution structure of human ubiquitin conjugating enzyme ube2g2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2g2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (165 residues) CATH domain: 3.10.110.10
2lwr
Solution structure of ring2 domain from parkin
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: park, cg10523. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: gst-fusion protein with tev cleavable tag.
Chain: A (68 residues) CATH domain: Unassigned
2lxp
Nmr structure of two domains in ubiquitin ligase gp78, ring bound to its conjugating enzyme ube2g
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2g2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: amfr, rnf45.
Chain: A (156 residues) CATH domain: 3.10.110.10
2m48
Solution structure of ibr-ring2 tandem domain from parkin
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: cg10523, park. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: modified to have tev site
Chain: A (141 residues) CATH domains: Unassigned Unassigned
2o25
Ubiquitin-conjugating enzyme e2-25 kda complexed with sumo-1 conjugating enzyme ubc9
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hip2, lig. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: ube2i, ubc9, ubce9.
Chains: A, B (199 residues) CATH domains: 3.10.110.10 1.10.8.10
2ob4
Human ubiquitin-conjugating enzyme cdc34
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc34, ube2r1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (157 residues) CATH domain: 3.10.110.10
2qgx
Ubiquitin-conjugating enzyme e2q
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2q1, nice5, ube2q. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C, D (156 residues) CATH domain: 3.10.110.10
2ucz
Ubiquitin conjugating enzyme (ubc7) from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Cellular_location: cytoplasm. Gene: ubc7. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (164 residues) CATH domain: 3.10.110.10
2y4w
Solution structure of human ubiquitin conjugating enzyme rad6b
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (152 residues) CATH domain: 3.10.110.10
2y9m
Pex4p-pex22p structure
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
Chain: A (166 residues) CATH domain: 3.10.110.10
2y9o
Pex4p-pex22p mutant i structure
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
Chain: A (166 residues) CATH domain: 3.10.110.10
2y9p
Pex4p-pex22p mutant ii structure
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
Chain: A (166 residues) CATH domain: 3.10.110.10
2yb6
Native human rad6
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (150 residues) CATH domain: 3.10.110.10
2ybf
Complex of rad18 (rad6 binding domain) with rad6b
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Chain: A (150 residues) CATH domain: 3.10.110.10
2yho
The idol-ube2d complex mediates sterol-dependent degradation ldl receptor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, D, F, H (149 residues) CATH domain: 3.10.110.10
2z5d
Human ubiquitin-conjugating enzyme e2 h
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2h. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (152 residues) CATH domain: 3.10.110.10
3a33
Ubch5b~ubiquitin conjugate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ubch5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (150 residues) CATH domain: 3.10.110.10
3bzh
Crystal structure of human ubiquitin-conjugating enzyme e2 e
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2e1, ubch6. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (161 residues) CATH domain: 3.10.110.10
3e46
Crystal structure of ubiquitin-conjugating enzyme e2-25kda (huntington interacting protein 2) m172a mutant
Source: Homo sapiens. Organism_taxid: 9606. Gene: ube2k, hip2, lig. Expressed in: escherichia coli.
Chain: A (202 residues) CATH domains: 3.10.110.10 1.10.8.10
3eb6
Structure of the ciap2 ring domain bound to ubch5b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: birc3, api2, iap1, mihc, rnf49. Expressed in: escherichia coli. Expression_system_taxid: 562. Xenopus laevis. Clawed frog, platanna. Organism_taxid: 8355.
Chain: B (149 residues) CATH domain: 3.10.110.10
3f92
Crystal structure of ubiquitin-conjugating enzyme e2-25kda (huntington interacting protein 2) m172a mutant crystallized at ph 8.5
Source: Homo sapiens. Organism_taxid: 9606. Gene: ube2k, hip2, lig. Expressed in: escherichia coli.
Chain: A (202 residues) CATH domains: 3.10.110.10 1.10.8.10
3fsh
Crystal structure of the ubiquitin conjugating enzyme ube2g2 bound to the g2br domain of ubiquitin ligase gp78
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ube2g2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized. This sequence occurs naturally in humans.
Chains: A, B (167 residues) CATH domain: 3.10.110.10
3h8k
Crystal structure of ube2g2 complxed with the g2br domain of 1.8-a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2g2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: amfr, rnf45.
Chain: A (164 residues) CATH domain: 3.10.110.10
3hct
Crystal structure of traf6 in complex with ubc13 in the p1 space group
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rnf85, traf6. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: blu, ube2n.
Chain: B (148 residues) CATH domain: 3.10.110.10
3hcu
Crystal structure of traf6 in complex with ubc13 in the c2 space group
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rnf85, traf6. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: blu, ube2n.
Chains: B, D (150 residues) CATH domain: 3.10.110.10
3jvz
E2~ubiquitin-hect
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d2, ubc4, ubch5b. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: nedd4l, kiaa0439, nedl3. Expression_system_taxid: 562
Chains: A, B (146 residues) CATH domain: 3.10.110.10
3jw0
E2~ubiquitin-hect
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d2, ubc4, ubch5b. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: nedd4l, kiaa0439, nedl3. Gene: rps27a, uba80, ubcep1, uba52, ubcep2, ubb, ubc.
Chains: A, B (146 residues) CATH domain: 3.10.110.10
3k9o
The crystal structure of e2-25k and ubb+1 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2k, hip2, lig. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ubb. Expression_system_taxid: 562
Chain: A (198 residues) CATH domains: 3.10.110.10 1.10.8.10
3k9p
The crystal structure of e2-25k and ubiquitin complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2k, hip2, lig. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: A (199 residues) CATH domains: 3.10.110.10 1.10.8.10
3l1y
Crystal structure of human ubc4 e2 conjugating enzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d2, ubc4, ubch5b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (152 residues) CATH domain: 3.10.110.10
3l1z
Crystal structure of the u-box domain of human e4b ubiquitin complex with ubch5c e2 ubiquitin conjugating enzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d3, ubch5c. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ube4b, hdnb1, kiaa0684, ufd2.
Chain: A (152 residues) CATH domain: 3.10.110.10
3oj4
Crystal structure of the a20 znf4, ubiquitin and ubch5a comp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d1, sft, ubc5a, ubch5, ubch5a. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: ubb. Gene: tnfaip3, otud7c.
Chains: A, D (147 residues) CATH domain: 3.10.110.10
3ptf
X-ray structure of the non-covalent complex between ubch5a a ubiquitin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sft, ubc5a, ubch5, ubch5a, ube2d1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ubiquitin.
Chains: A, B (153 residues) CATH domain: 3.10.110.10
3rpg
Bmi1/ring1b-ubch5c complex structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d3, ubc5c, ubch5c. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmi1, pcgf4, rnf51. Gene: rnf2, bap1, ding, hipi3, ring1b. Expression_system_taxid: 562
Chain: A (149 residues) CATH domain: 3.10.110.10
3rz3
Human cdc34 e2 in complex with cc0651 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc34, ubch3, ube2r1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (164 residues) CATH domain: 3.10.110.10
3sqv
Crystal structure of e. Coli o157:h7 e3 ubiquitin ligase, nl human e2, ubch7
Source: Escherichia coli. Organism_taxid: 83334. Strain: o157:h7. Gene: ecs1560. Expressed in: escherichia coli. Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.
Chains: C, D (147 residues) CATH domain: 3.10.110.10
3sy2
Crystal structure of the salmonella e3 ubiquitin ligase sopa complex with the human e2 ubch7
Source: Salmonella enterica subsp. Enterica se typhimurium. Organism_taxid: 90371. Gene: sopa, stm2066. Expressed in: escherichia coli. Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.
Chains: C, D (154 residues) CATH domain: 3.10.110.10
3tgd
Crystal structure of the human ubiquitin-conjugating enzyme ubch5b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ubc4, ubc5b, ubch4, ubch5b, ube2d2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (152 residues) CATH domain: 3.10.110.10
3ugb
Ubch5c~ubiquitin conjugate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ubc5c, ubch5c, ube2d2, ube2d3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ubc.
Chain: A (146 residues) CATH domain: 3.10.110.10
3von
Crystalstructure of the ubiquitin protease
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hspc263, otb1, otu1, otub1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mms2, ube2v2, uev2. Gene: blu, ubc13, ube2n.
Chains: C, E, G, J, L, N, Q, S, U, X, Z, b, e, g, i, l, n, p (147 residues) CATH domain: 3.10.110.10
3w31
Structual basis for the recognition of ubc13 by the shigella effector ospi
Source: Shigella flexneri. Organism_taxid: 623. Gene: orf169b, cp0209. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2n, blu.
Chain: B (152 residues) CATH domain: 3.10.110.10
3zni
Structure of phosphotyr363-cbl-b - ubch5b-ub - zap-70 peptid
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Expression_system_taxid: 562
Chains: C, G, K, O (146 residues) CATH domain: 3.10.110.10
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein
4a49
Structure of phosphotyr371-c-cbl-ubch5b complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chain: B (146 residues) CATH domain: 3.10.110.10
4a4b
Structure of modified phosphotyr371-c-cbl-ubch5b-zap-70 comp
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold. Synthetic: yes.
Chain: C (146 residues) CATH domain: 3.10.110.10
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein
4a4c
Structure of phosphotyr371-c-cbl-ubch5b-zap-70 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold. Synthetic: yes.
Chain: C (145 residues) CATH domain: 3.10.110.10
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein
4ap4
Rnf4 - ubch5a - ubiquitin heterotrimeric complex
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chains: B, E (151 residues) CATH domain: 3.10.110.10
4auq
Structure of birc7-ubch5b-ub complex.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, D (146 residues) CATH domain: 3.10.110.10
4b8e
Pry-spry domain of trim25
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (194 residues) CATH domain: Unassigned
4bvu
Structure of shigella effector ospg in complex with host ubch5c-ubiquitin conjugate
Source: Shigella flexneri. Organism_taxid: 623. Expressed in: escherichia coli. Expression_system_taxid: 511693. Homo sapiens. Human. Organism_taxid: 9606.
Chain: B (146 residues) CATH domain: 3.10.110.10
4bwf
Pex4p-pex22p disulphide bond mutant
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
Chain: A (166 residues) CATH domain: 3.10.110.10
4ccg
Structure of an e2-e3 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (157 residues) CATH domain: 3.10.110.10
4ddg
Crystal structure of human otub1/ubch5b~ub/ub
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: e2, hspc263, otb1, otu1, otub1, ubc4, ubc5b, ubch4, u ube2d2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ubc. Expression_system_taxid: 562
Chains: A, B, C, J, K, L (399 residues) CATH domain: 3.10.110.10
4ddi
Crystal structure of human otub1/ubch5b~ub/ub
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2d2, ubc4, ubc5b, ubch4, ubch5b, hspc263, otb1, ot otub1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ubc. Expression_system_taxid: 562
Chains: G, H, I ( residues)
4dhi
Structure of c. Elegans otub1 bound to human ubc13
Source: Caenorhabditis elegans. Nematode. Organism_taxid: 6239. Gene: otub-1, c25d7.8. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
Chain: D (150 residues) CATH domain: 3.10.110.10
4dhj
The structure of a ceotub1 ubiquitin aldehyde ubc13~ub compl
Source: Caenorhabditis elegans. Nematode. Organism_taxid: 6239. Gene: otub-1, c25d7.8. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
Chains: C, K, G, N (149 residues) CATH domain: 3.10.110.10
4dhz
The structure of h/ceotub1-ubiquitin aldehyde-ubc13~ub
Source: Homo sapiens, caenorhabditis elegans. Human, nematode. Organism_taxid: 9606, 6239. Gene: otub1, otb1, otu1, hspc263, c25d7.8, otub-1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
Chain: F (149 residues) CATH domain: 3.10.110.10
4epo
Crystal structure of rnf8 bound to the ubc13/mms2 heterodime
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2v2, mms2, uev2. Expressed in: escherichia coli. Expression_system_taxid: 511693. Gene: ube2n, blu. Gene: rnf8, kiaa0646.
Chains: B, F, J (147 residues)
4fh1
S. Cerevisiae ubc13-n79a
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: ubc13, ydr092w, yd6652.04. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (145 residues) CATH domain: 3.10.110.10
Bound ligand:   Het Group NHE is 42.11% similar to enzyme reactant protein
4ii2
Crystal structure of ubiquitin activating enzyme 1 (uba1) in with the ub e2 ubc4, ubiquitin, and atp/mg
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 284812. Strain: 972 / atcc 24843. Gene: ptr3, spbc1604.21c, spbc211.09, ubiquitin activating (uba1). Expressed in: escherichia coli. Expression_system_taxid: 562. Strain: strain 972 / atcc 24843.
Chain: C (149 residues) CATH domain: 3.10.110.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4ip3
Complex structure of ospi and ubc13
Source: Shigella flexneri. Organism_taxid: 623. Strain: 301. Gene: cp0209, orf169b, ospi. Expressed in: escherichia coli. Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.
Chain: B (151 residues) CATH domain: 3.10.110.10
4jqu
Crystal structure of ubc7p in complex with the u7br of cue1p
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: qri8, ubc7, ubc7p, ym9711.12, ymr022w. Expressed in: escherichia coli. Expression_system_taxid: 511693. Gene: cue1, cue1p, kis4, ym8156.06, ymr264w.
Chain: A (163 residues) CATH domain: 3.10.110.10
4lad
Crystal structure of the ube2g2:ring-g2br complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2g2, ubiquitin-conjugating enzyme e2g2 isoform 1. Expressed in: escherichia coli. Expression_system_taxid: 511693. Gene: amfr, autocrine motility factor receptor, rnf45.
Chain: A (154 residues) CATH domain: 3.10.110.10
4ldt
The structure of h/ceotub1-ubiquitin aldehyde-ubch5b~ub
Source: Homo sapiens, caenorhabditis elegans. Human, nematode. Organism_taxid: 9606, 6239. Gene: otub1, otb1, otu1, hspc263, c25d7.8, otub-1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
Chain: C (148 residues) CATH domain: 3.10.110.10
4mdk
Cdc34-ubiquitin-cc0651 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc34, ubch3, ube2r1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: ubc.
Chains: A, B, C, D (168 residues) CATH domain: 3.10.110.10
4orh
Crystal structure of rnf8 bound to the ubc13/mms2 heterodime
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mms2, ube2v2, uev2. Expressed in: escherichia coli. Expression_system_taxid: 511693. Gene: ube2n, blu. Gene: rnf8, kiaa0646.
Chains: B, F, J (148 residues)
4q5e
Shigella effector kinase ospg bound to e2-ub ubch7-ub conjug
Source: Shigella sonnei ss046. Organism_taxid: 300269. Strain: 2457t. Gene: ospg, sson_p170. Expressed in: escherichia coli. Expression_system_taxid: 469008. Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292.
Chain: C (155 residues) CATH domain: 3.10.110.10
4q5h
Shigella effector kinase ospg bound to amppnp and e2-ub ubch conjugate
Source: Shigella sonnei. Organism_taxid: 300269. Strain: 2457t. Gene: ospg, sson_p170. Expressed in: escherichia coli. Expression_system_taxid: 469008. Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292.
Chain: C (155 residues) CATH domain: 3.10.110.10