_EC 6.2.1.5 Succinate--CoA ligase (ADP-forming). 21 PDB entries  
EC 6.-.-.- Ligases. [1,580 PDB entries]
EC 6.2.-.- Forming carbon-sulfur bonds. [60 PDB entries]
EC 6.2.1.- Acid--thiol ligases. [60 PDB entries]
EC 6.2.1.5 Succinate--CoA ligase (ADP-forming). [21 PDB entries]    
1cqi

Reaction: Atp + succinate + CoA = adp + phosphate + succinyl-CoA.
 


ATP
+
succinate
+
CoA
=
ADP
+
phosphate
+
succinyl-CoA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Succinate thiokinase. Succinyl-CoA synthetase (ADP-forming).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 21 PDB entries in enzyme class E.C.6.2.1.5

  PDB code Protein
1cqi
Crystal structure of the complex of adp and mg2+ with dephosphorylated e. Coli succinyl-coa synthetase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, D, E (286 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligands:   Het Group PO4 corresponds to enzyme product phosphate
  Het Group COA is 87.00% similar to enzyme product succinyl-CoA
1cqj
Crystal structure of dephosphorylated e. Coli succinyl-coa synthetase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, D, E (286 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligands:   Het Group PO4 corresponds to enzyme product phosphate
  Het Group COA is 87.00% similar to enzyme product succinyl-CoA
1euc
Crystal structure of dephosphorylated pig heart, gtp- specific succinyl-coa synthetase
Source: Sus scrofa. Pig. Organism_taxid: 9823. Tissue: heart. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (306 residues) CATH domains: 3.40.50.720 3.40.50.261
1eud
Crystal structure of phosphorylated pig heart, gtp-specific succinyl-coa synthetase
Source: Sus scrofa. Pig. Organism_taxid: 9823. Tissue: heart. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (306 residues) CATH domains: 3.40.50.720 3.40.50.261
1jkj
E. Coli scs
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, D, E (287 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligands:   Het Group GOL is 40.00% similar to enzyme reactant succinate
  Het Group COA corresponds to enzyme reactant CoA
  Het Group PO4 corresponds to enzyme product phosphate
1jll
Crystal structure analysis of the e197betaa mutant of e. Coli scs
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, D, E (287 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligands:   Het Group PO4 corresponds to enzyme product phosphate
  Het Group COA is 76.00% similar to enzyme product succinyl-CoA
1oi7
The crystal structure of succinyl-coa synthetase alpha subunit from thermus thermophilus
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (270 residues) CATH domains: 3.40.50.720 3.40.50.261
1scu
The crystal structure of succinyl-coa synthetase from escherichia coli at 2.5 angstroms resolution
Source: Escherichia coli. Organism_taxid: 562. Organism_taxid: 562
Chains: A, B, D, E (288 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligand:   Het Group COA is 87.00% similar to enzyme product succinyl-CoA
2fp4
Crystal structure of pig gtp-specific succinyl-coa synthetase in complex with gtp
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: suclg1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: suclg2.
Chain: A (305 residues) CATH domains: 3.40.50.720 3.40.50.261
2fpg
Crystal structure of pig gtp-specific succinyl-coa synthetase in complex with gdp
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: suclg1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: suclg2.
Chain: A (305 residues) CATH domains: 3.40.50.720 3.40.50.261
2fpi
Crystal structure of pig gtp-specific succinyl-coa synthetase from polyethylene glycol
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: suclg1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: suclg2.
Chain: A (305 residues) CATH domains: 3.40.50.720 3.40.50.261
2fpp
Crystal structure of pig gtp-specific succinyl-coa synthetase from polyethylene glycol with chloride ions
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: suclg1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: suclg2.
Chain: A (305 residues) CATH domains: 3.40.50.720 3.40.50.261
2nu6
C123aa mutant of e. Coli succinyl-coa synthetase
Source: Escherichia coli. Organism_taxid: 562. Gene: sucd. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: succ.
Chains: A, B, D, E (287 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligand:   Het Group COA is 87.00% similar to enzyme product succinyl-CoA
2nu7
C123as mutant of e. Coli succinyl-coa synthetase
Source: Escherichia coli. Organism_taxid: 562. Gene: sucd. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: succ.
Chains: A, B, D, E (287 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligands:   Het Group PO4 corresponds to enzyme product phosphate
  Het Group COA is 87.00% similar to enzyme product succinyl-CoA
2nu8
C123at mutant of e. Coli succinyl-coa synthetase
Source: Escherichia coli. Organism_taxid: 562. Gene: sucd. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: succ.
Chains: A, B, D, E (287 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligands:   Het Group GOL is 40.00% similar to enzyme reactant succinate
  Het Group COA corresponds to enzyme reactant CoA
  Het Group PO4 corresponds to enzyme product phosphate
2nu9
C123at mutant of e. Coli succinyl-coa synthetase orthorhombic crystal form
Source: Escherichia coli. Organism_taxid: 562. Gene: sucd. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: succ.
Chains: A, B, D, E, F, G, H, I (286 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligand:   Het Group COA is 87.00% similar to enzyme product succinyl-CoA
2nua
C123av mutant of e. Coli succinyl-coa synthetase
Source: Escherichia coli. Organism_taxid: 562. Gene: sucd. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: succ.
Chains: B, D, E (388 residues) CATH domains: 3.30.470.20 3.30.1490.20 3.40.50.261
Bound ligands:   Het Group PO4 corresponds to enzyme product phosphate
  Het Group COA is 87.00% similar to enzyme product succinyl-CoA
2scu
A detailed description of the structure of succinyl-coa synthetase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Strain: cr63. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, D, E (286 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligand:   Het Group COA is 87.00% similar to enzyme product succinyl-CoA
2yv1
Crystal structure of succinyl-coa synthetase alpha chain fro methanocaldococcus jannaschii dsm 2661
Source: Methanocaldococcus jannaschii. Organism_taxid: 243232. Strain: dsm 2661. Gene: sucd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (268 residues) CATH domains: 3.40.50.720 3.40.50.261
2yv2
Crystal structure of succinyl-coa synthetase alpha chain fro aeropyrum pernix k1
Source: Aeropyrum pernix. Organism_taxid: 272557. Strain: k1. Gene: sucd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (269 residues) CATH domains: 3.40.50.720 3.40.50.261
3ufx
Thermus aquaticus succinyl-coa synthetase in complex with gd
Source: Thermus aquaticus. Organism_taxid: 271. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, D, E, F, G, H, I (288 residues) CATH domains: 3.40.50.720 3.40.50.261
Bound ligand:   Het Group GDP is 96.43% similar to enzyme product ADP