_EC 6.1.1.18 Glutamine--tRNA ligase. 22 PDB entries  
EC 6.-.-.- Ligases. [1,591 PDB entries]
EC 6.1.-.- Forming carbon-oxygen bonds. [549 PDB entries]
EC 6.1.1.- Ligases forming aminoacyl-tRNA and related compounds. [548 PDB entries]
EC 6.1.1.18 Glutamine--tRNA ligase. [22 PDB entries]    
1euq

Reaction: Atp + L-glutamine + tRNA(Gln) = amp + diphosphate + L-glutaminyl- tRNA(Gln).
 


ATP
+
L-glutamine
+
tRNA(Gln)
=
AMP
+
diphosphate
+
L-glutaminyl- tRNA(Gln)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Glutamine translase. Glutaminyl-tRNA synthetase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 22 PDB entries in enzyme class E.C.6.1.1.18

  PDB code Protein
1euq
Crystal structure of glutaminyl-tRNA synthetase complexed wi gln mutant and an active-site inhibitor
Source: Synthetic: yes. Other_details: product of runoff t7 polymerase transcriptio synthetic DNA template. Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligand:   Het Group QSI is 52.78% similar to enzyme product AMP
1euy
Glutaminyl-tRNA synthetase complexed with a tRNA mutant and an active site inhibitor
Source: Synthetic: yes. Other_details: product of runoff t7 polymerase transcription from synthetic DNA template. Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligand:   Het Group QSI is 52.00% similar to enzyme product AMP
1exd
Crystal structure of a tight-binding glutamine tRNA bound to glutamine aminoacyl tRNA synthetase
Source: Synthetic: yes. Other_details: product of runoff t7 polymerase transcription from synthetic DNA template. Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligand:   Het Group A is 95.00% similar to enzyme product AMP
1gsg
Structure of e.Coli glutaminyl-tRNA synthetase complexed wit and atp at 2.8 angstroms resolution
Source: Synthetic: yes. Escherichia coli. Organism_taxid: 562
Chain: P (526 residues)
1gtr
Structural basis of anticodon loop recognition by glutaminyl synthetase
Source: Synthetic: yes. Escherichia coli. Organism_taxid: 562
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1gts
Structural basis for transfer RNA aminoaceylation by escherichia coli glutaminyl-tRNA synthetase
Source: Escherichia coli. Organism_taxid: 562. Organism_taxid: 562
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligand:   Het Group AMP corresponds to enzyme product AMP
1nyl
Unliganded glutaminyl-tRNA synthetase
Source: Escherichia coli. Organism_taxid: 562. Gene: glns. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (523 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
1o0b
Crystal structure of l-glutamine and ampcpp bound to glutamine aminoacyl tRNA synthetase
Source: Synthetic: yes. Other_details: product of runoff t7 polymerase transcription from a double helical DNA template. Escherichia coli. Organism_taxid: 562. Gene: glns. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligands:   Het Group GLN corresponds to enzyme reactant L-glutamine
  Het Group AMP is 82.00% similar to enzyme product AMP
1o0c
Crystal structure of l-glutamate and ampcpp bound to glutamine aminoacyl tRNA synthetase
Source: Synthetic: yes. Other_details: product of runoff t7 polymerase transcription from a double helical DNA template. Escherichia coli. Organism_taxid: 562. Gene: glns. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligands:   Het Group GLU is 81.00% similar to enzyme reactant L-glutamine
  Het Group AMP corresponds to enzyme product AMP
1qrs
Glutaminyl-tRNA synthetase mutant d235n complexed with glutamine transfer RNA
Source: Escherichia coli. Organism_taxid: 562. Strain: k-12. Variant: deltah1deltatrp. Gene: trnagln2. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: lambda pl promoter. Strain: x3r2 (glns deletion strain).
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1qrt
Glutaminyl-tRNA synthetase mutant d235g complexed with glutamine transfer RNA
Source: Escherichia coli. Organism_taxid: 562. Strain: k-12. Variant: deltah1deltatrp. Gene: trnagln2. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: lambda pl promoter. Strain: x3r2 (glns deletion strain).
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1qru
Glutaminyl-tRNA synthetase mutant i129t complexed with glutamine transfer RNA
Source: Escherichia coli. Organism_taxid: 562. Strain: k-12. Variant: deltah1deltatrp. Gene: trnagln2. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: lambda pl promoter. Strain: x3r2 (glns deletion strain).
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1qtq
Glutaminyl-tRNA synthetase complexed with tRNA and an amino acid analog
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: A (529 residues) CATH domains: 2.40.240.10 2.40.240.10 1.10.1160.10 3.90.800.10 3.40.50.620
Bound ligand:   Het Group QSI is 52.00% similar to enzyme product AMP
1zjw
Glutaminyl-tRNA synthetase complexed to glutamine and 2'deoxy a76 glutamine tRNA
Source: Synthetic: yes. Other_details: in vitro transcribed RNA. Escherichia coli. Organism_taxid: 562. Gene: glns. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (529 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 2.40.240.10 2.40.240.10
Bound ligands:   Het Group GLN corresponds to enzyme reactant L-glutamine
  Het Group AMP corresponds to enzyme product AMP
2hz7
Crystal structure of the glutaminyl-tRNA synthetase from deinococcus radiodurans
Source: Deinococcus radiodurans. Organism_taxid: 1299. Gene: glns. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (556 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 2.40.240.10 2.40.240.10
2rd2
Glutaminyl-tRNA synthetase mutant c229r with bound analog 5' glutaminyl)-sulfamoyl]adenosine
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: glns. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: tRNA synthesized in vitro from a 100 nucleot template
Chain: A (529 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 2.40.240.10 2.40.240.10
Bound ligand:   Het Group QSI is 52.78% similar to enzyme product AMP
2re8
Glutaminyl-tRNA synthetase mutant c229r with bound analog 5'-o-[n-(l-glutamyl)-sulfamoyl]adenosine
Source: Escherichia coli. Organism_taxid: 562. Gene: glns. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: q2 tRNA synthesized in vitro from a 100 basepair DNA template
Chain: A (529 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 2.40.240.10 2.40.240.10
Bound ligand:   Het Group GSU is 52.00% similar to enzyme product AMP
3tl4
Crystal structure of the tRNA binding domain of glutaminyl-t synthetase from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: gln4, o3601, yor168w. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chain: X (186 residues) CATH domains: Unassigned Unassigned
4h3s
The structure of glutaminyl-tRNA synthetase from saccharomyc cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: bcy123. Gene: gln4, o3601, yor168w
Chain: A (585 residues) CATH domains: Unassigned 2.40.240.10
Bound ligand:   Het Group ACT is 40.00% similar to enzyme reactant L-glutamine
4jxx
Crystal structure of e coli e. Coli glutaminyl-tRNA syntheta to tRNA(gln)(cug) and atp from novel cryostabilization cond
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: glns, b0680, jw0666. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (536 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 2.40.240.10 2.40.240.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4jxz
Structure of e. Coli glutaminyl-tRNA synthetase bound to atp tRNA(gln) acceptor containing a uug anticodon
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: glns, b0680, jw0666. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic. Organism_taxid: 32630
Chain: A (538 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 2.40.240.10 2.40.240.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4jyz
Crystal structure of e. Coli glutaminyl-tRNA synthetase boun and native tRNA(gln) containing the cmnm5s2u34 anticodon wo
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: glns, b0680, jw0666. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 562
Chain: A (542 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 2.40.240.10 2.40.240.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP