_EC 6.1.1.17 Glutamate--tRNA ligase. 29 PDB entries  
EC 6.-.-.- Ligases. [1,425 PDB entries]
EC 6.1.-.- Forming carbon-oxygen bonds. [471 PDB entries]
EC 6.1.1.- Ligases forming aminoacyl-tRNA and related compounds. [470 PDB entries]
EC 6.1.1.17 Glutamate--tRNA ligase. [29 PDB entries]    
1d2d

Reaction: Atp + L-glutamate + tRNA(Glu) = amp + diphosphate + L-glutamyl-tRNA(Glu).
 


ATP
+
L-glutamate
+
tRNA(Glu)
=
AMP
+
diphosphate
+
L-glutamyl-tRNA(Glu)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Glutamic acid translase. Glutamyl-tRNA synthetase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 29 PDB entries in enzyme class E.C.6.1.1.17

  PDB code Protein
1d2d
Hamster eprs second repeated element. Nmr, 5 structures
Source: Cricetulus griseus. Chinese hamster. Organism_taxid: 10029. Organ: ovary cells. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (56 residues) CATH domain: 1.10.287.10
1fyj
Solution structure of multi-functional peptide motif-1 present in human glutamyl-prolyl tRNA synthetase (eprs).
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (57 residues) CATH domain: 1.10.287.10
1g59
Glutamyl-tRNA synthetase complexed with tRNA(glu).
Source: Synthetic: yes. Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (468 residues) CATH domains: 3.40.50.620 1.10.1160.10 3.90.800.10 1.10.8.70 1.10.10.350
1gln
Architectures of class-defining and specific domains of glut synthetase
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8
Chain: A (468 residues) CATH domains: 3.40.50.620 1.10.1160.10 3.90.800.10 1.10.8.70 1.10.10.350
1j09
Crystal structure of thermus thermophilus glutamyl-tRNA synthetase complexed with atp and glu
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (468 residues) CATH domains: 3.40.50.620 1.10.1160.10 3.90.800.10 1.10.8.70 1.10.10.350
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group GLU corresponds to enzyme reactant
1n75
Crystal structure of thermus thermophilus glutamyl-tRNA synthetase complexed with atp.
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (468 residues) CATH domains: 3.40.50.620 1.10.1160.10 3.90.800.10 1.10.8.70 1.10.10.350
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1n77
Crystal structure of thermus thermophilus glutamyl-tRNA synthetase complexed with tRNA(glu) and atp.
Source: Synthetic: yes. Other_details: this t-RNA occurs from thermus thermophilus, in vitro transcription. Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (468 residues) CATH domains: 3.40.50.620 1.10.1160.10 3.90.800.10 1.10.8.70 1.10.10.350
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1n78
Crystal structure of thermus thermophilus glutamyl-tRNA synthetase complexed with tRNA(glu) and glutamol-amp.
Source: Synthetic: yes. Other_details: this t-RNA occurs from thermus thermophilus, in vitro transcription. Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (468 residues) CATH domains: 3.40.50.620 1.10.1160.10 3.90.800.10 1.10.8.70 1.10.10.350
Bound ligand:   Het Group GOM is 74.00% similar to enzyme product ATP
1r1b
Eprs second repeated element, nmr, minimized average structure
Source: Cricetulus griseus. Chinese hamster. Organism_taxid: 10029. Organ: ovary cells. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (56 residues) CATH domain: 1.10.287.10
2cuz
Glutamyl-tRNA synthetase from thermus thermophilus in complex with l-glutamate
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (468 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 1.10.8.70 1.10.10.350
Bound ligand:   Het Group GLU corresponds to enzyme reactant ATP
2cv0
Glutamyl-tRNA synthetase from thermus thermophilus in complex with tRNA(glu) and l-glutamate
Source: Synthetic: yes. Other_details: in vitro transcription. Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (468 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 1.10.8.70 1.10.10.350
Bound ligand:   Het Group GLU corresponds to enzyme reactant ATP
2cv1
Glutamyl-tRNA synthetase from thermus thermophilus in complex with tRNA(glu), atp, and an analog of l-glutamate: a quaternary complex
Source: Synthetic: yes. Other_details: in vitro transcription. Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (468 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 1.10.8.70 1.10.10.350
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group GAU is 90.00% similar to enzyme reactant
2cv2
Glutamyl-tRNA synthetase from thermus thermophilus in complex with tRNA(glu) and an enzyme inhibitor, glu-ams
Source: Synthetic: yes. Other_details: in vitro transcription. Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (468 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 1.10.8.70 1.10.10.350
Bound ligand:   Het Group GSU is 52.00% similar to enzyme product ATP
2dxi
2.2 a crystal structure of glutamyl-tRNA synthetase from thermus thermophilus complexed with tRNA(glu), atp, and l- glutamol
Source: Synthetic: yes. Other_details: in vitro transcription. Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (468 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 1.10.8.70 1.10.10.350
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group GAU is 90.00% similar to enzyme reactant
2hra
Crystal structures of the interacting domains from yeast glu synthetase and tRNA aminoacylation and nuclear export cofac reveal a novel function for an old fold
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gus1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (180 residues) CATH domains: Unassigned 1.20.1050.10
2hrk
Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub- complexes
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gus1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: arc1.
Chain: A (177 residues) CATH domains: Unassigned 1.20.1050.10
2hsm
Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub- complexes
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gus1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: arc1.
Chain: A (178 residues) CATH domains: Unassigned 1.20.1050.10
2ja2
Mycobacterium tuberculosis glutamyl-tRNA synthetase
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: p53b
Chain: A (485 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 Unassigned 1.10.10.350
Bound ligand:   Het Group ACT is 40.00% similar to enzyme reactant ATP
2o5r
Crystal structure of glutamyl-tRNA synthetase 1 (ec 6.1.1.17 (glutamate-tRNA ligase 1) (glurs 1) (tm1351) from thermotog at 2.5 a resolution
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: gltx1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (468 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 1.10.8.70 1.10.10.350
3afh
Crystal structure of thermotoga maritima nondiscriminating g tRNA synthetase in complex with a glutamyl-amp analog
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (463 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 Unassigned 1.10.10.350
Bound ligand:   Het Group GSU is 52.00% similar to enzyme product ATP
3aii
Archaeal non-discriminating glutamyl-tRNA synthetase from methanothermobacter thermautotrophicus
Source: Methanothermobacter thermautotrophicus organism_taxid: 187420. Strain: str. Delta h. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (455 residues) CATH domains: 0.0.0.0 0.0.0.0 0.0.0.0
Bound ligand:   Het Group ACY is 40.00% similar to enzyme reactant ATP
3akz
Crystal structure of thermotoga maritima nondiscriminating g tRNA synthetase in complex with trnagln and a glutamyl-amp
Source: Thermotoga maritima. Organism_taxid: 243274. Strain: msb8. Gene: gltx2, tm_1875. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: t7 transcription
Chains: B, D, C, A (463 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 Unassigned 1.10.10.350
Bound ligand:   Het Group GSU is 52.00% similar to enzyme product ATP
3pnv
V369m mutant of glutamyl-tRNA synthetase from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: glts, gltx, mt3070, mtv012.06c, rv2992c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (481 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 Unassigned 1.10.10.350
3pny
Structure of glutamyl-tRNA synthetase from mycobacterium tub in space group p21
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: glts, gltx, mt3070, mtv012.06c, rv2992c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (481 residues) CATH domains: 3.40.50.620 3.90.800.10 1.10.1160.10 Unassigned 1.10.10.350
4g6z
Crystal structure of a glutamyl-tRNA synthetase glurs from burkholderia thailandensis bound to l-glutamate
Source: Burkholderia thailandensis. Organism_taxid: 271848. Strain: e264 / atcc 700388 / dsm 13276 / cip 106301. Gene: bth_i1984, gltx. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (380 residues) CATH domains: 0.0.0.0 0.0.0.0
Bound ligand:   Het Group GLU corresponds to enzyme reactant ATP
4hvc
Crystal structure of human prolyl-tRNA synthetase in complex halofuginone and atp analogue
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eprs, glns, pars, qars, qprs, pig32. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (482 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
4k86
Crystal structure of human prolyl-tRNA synthetase (apo form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eprs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (488 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
4k87
Crystal structure of human prolyl-tRNA synthetase (substrate form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eprs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (490 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
4k88
Crystal structure of human prolyl-tRNA synthetase (halofugin form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eprs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (490 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30