_EC 6.1.1.13 D-alanine--poly(phosphoribitol) ligase. 12 PDB entries  
EC 6.-.-.- Ligases. [1,622 PDB entries]
EC 6.1.-.- Forming carbon-oxygen bonds. [563 PDB entries]
EC 6.1.1.- Ligases forming aminoacyl-tRNA and related compounds. [552 PDB entries]
EC 6.1.1.13 D-alanine--poly(phosphoribitol) ligase. [12 PDB entries]    
1dv5

Reaction: Atp + D-alanine + poly(ribitol phosphate) = amp + diphosphate + O-D- alanyl-poly(ribitol phosphate).
 


ATP
+
D-alanine
+
poly(ribitol phosphate)
=
AMP
+
diphosphate
+
O-D- alanyl-poly(ribitol phosphate)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): D-alanine-activating enzyme. D-alanine-D-alanyl carrier protein ligase. D-alanine-membrane acceptor ligase. D-alanine: membrane acceptor ligase. D-alanyl-poly(phosphoribitol) synthetase.
Comments: A thioester bond is formed transiently between D-alanine and the sulfhydryl group of the 4'-phosphopantetheine prosthetic group of D-alanyl carrier protein during the activation of the alanine. Involved in the synthesis of teichoic acids.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 12 PDB entries in enzyme class E.C.6.1.1.13

  PDB code Protein
1dv5
Tertiary structure of apo-d-alanyl carrier protein
Source: Lactobacillus casei. Organism_taxid: 1582. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (80 residues) CATH domain: 1.10.1200.10
1hqb
Tertiary structure of apo-d-alanyl carrier protein
Source: Lactobacillus casei. Organism_taxid: 1582. Gene: dltc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (80 residues) CATH domain: 1.10.1200.10
3dhv
Crystal structure of dlta protein in complex with d-alanine adenylate
Source: Bacillus cereus. Organism_taxid: 226900. Strain: atcc 14579. Gene: dlta. Expressed in: escherichia coli.
Chain: A (498 residues) CATH domains: Unassigned 3.30.300.30
Bound ligands:   Het Group DAL is 83.00% similar to enzyme reactant D-alanine
  Het Group AMP corresponds to enzyme product AMP
3e7w
Crystal structure of dlta: implications for the reaction mechanism of non-ribosomal peptide synthetase (nrps) adenylation domains
Source: Bacillus subtilis. Organism_taxid: 1423. Gene: dlta. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (508 residues) CATH domains: Unassigned 3.30.300.30
Bound ligands:   Het Group AMP corresponds to enzyme product AMP
  Het Group PO4 is 55.00% similar to enzyme product diphosphate
3e7x
Crystal structure of dlta: implications for the reaction mechanism of non-ribosomal peptide synthetase (nrps) adenylation domains
Source: Bacillus subtilis. Organism_taxid: 1423. Gene: dlta. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (508 residues) CATH domains: Unassigned 3.30.300.30
Bound ligand:   Het Group AMP corresponds to enzyme product AMP
3fcc
Crystal structure of dlta protein in complex with atp and ma
Source: Bacillus cereus. Organism_taxid: 226900. Strain: atcc 14579. Gene: bc_1372, dlta. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (500 residues) CATH domains: Unassigned 3.30.300.30
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
3fce
Crystal structure of bacillus cereus d-alanyl carrier protei dlta in complex with atp: implications for adenylation mech
Source: Bacillus cereus. Organism_taxid: 226900. Strain: atcc 14579. Gene: bc_1372, dlta. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (500 residues) CATH domains: Unassigned 3.30.300.30
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
3l8c
Structure of probable d-alanine--poly(phosphoribitol) ligase subunit-1 from streptococcus pyogenes
Source: Streptococcus pyogenes serotype m6. Organism_taxid: 301450. Gene: dlta, m6_spy1043. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (499 residues) CATH domains: Unassigned 3.30.300.30
3lgx
Structure of probable d-alanine-poly(phosphoribitol) ligase subunit-1 from streptococcus pyogenes with atp
Source: Streptococcus pyogenes. Organism_taxid: 160490. Strain: m1 gas. Gene: dlta, m5005_spy1073, spy_1312. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (508 residues) CATH domains: Unassigned 3.30.300.30
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4bpf
High resolution crystal structure of bacillus subtilis dltc
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (86 residues)
4bpg
Crystal structure of bacillus subtilis dltc
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (80 residues)
4bph
High resolution crystal structure of bacillus subtilis dltc
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (85 residues)
Bound ligand:   Het Group PNS is 42.31% similar to enzyme reactant poly(ribitol