_EC 6.1.1.10 Methionine--tRNA ligase. 66 PDB entries  
EC 6.-.-.- Ligases. [1,638 PDB entries]
EC 6.1.-.- Forming carbon-oxygen bonds. [571 PDB entries]
EC 6.1.1.- Ligases forming aminoacyl-tRNA and related compounds. [560 PDB entries]
EC 6.1.1.10 Methionine--tRNA ligase. [66 PDB entries]    
1a8h

Reaction: Atp + L-methionine + tRNA(Met) = amp + diphosphate + L-methionyl- tRNA(Met).
 


ATP
+
L-methionine
+
tRNA(Met)
=
AMP
+
diphosphate
+
L-methionyl- tRNA(Met)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Methionine translase. Methionyl-transfer ribonucleate synthetase. Methionyl-transfer ribonucleic acid synthetase. Methionyl-transfer Rna synthetase. Methionyl-tRNA synthetase. MetRS.
Comments: In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for Ec 2.1.2.9.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 66 PDB entries in enzyme class E.C.6.1.1.10

  PDB code Protein
1a8h
Methionyl-tRNA synthetase from thermus thermophilus
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8
Chain: A (500 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
1f4l
Crystal structure of the e.Coli methionyl-tRNA synthetase co with methionine
Source: Escherichia coli. Organism_taxid: 562. Gene: synthetic gene. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (545 residues) CATH domains: 2.20.28.20 3.40.50.620 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
1mea
Methionyl-tRNA synthetase zinc binding domain. 3d structure and homology with rubredoxin and gag retroviral proteins
Source: Escherichia coli. Organism_taxid: 562. Gene: gag.
Chain: A (28 residues)
1med
Methionyl-tRNA synthetase zinc binding domain. 3d structure and homology with rubredoxin and gag retroviral proteins
Source: Escherichia coli. Organism_taxid: 562. Gene: gag.
Chain: A (28 residues)
1mkh
C-terminal domain of methionyl-tRNA synthetase from pyrococc
Source: Pyrococcus abyssi. Organism_taxid: 29292. Gene: metg. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (106 residues) CATH domain: 2.40.50.140
1p7p
Methionyl-tRNA synthetase from escherichia coli complexed with methionine phosphonate
Source: Escherichia coli. Organism_taxid: 562. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (545 residues) CATH domains: 2.20.28.20 3.40.50.620 1.10.730.10
Bound ligand:   Het Group MPH is 46.00% similar to enzyme reactant L-methionine
1pfu
Methionyl-tRNA synthetase from escherichia coli complexed with methionine phosphinate
Source: Escherichia coli. Organism_taxid: 562. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (547 residues) CATH domains: 2.20.28.20 3.40.50.620 1.10.730.10
Bound ligand:   Het Group MPJ is 50.00% similar to enzyme reactant L-methionine
1pfv
Methionyl-tRNA synthetase from escherichia coli complexed with difluoromethionine
Source: Escherichia coli. Organism_taxid: 562. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (547 residues) CATH domains: 2.20.28.20 3.40.50.620 1.10.730.10
Bound ligand:   Het Group 2FM is 81.00% similar to enzyme reactant L-methionine
1pfw
Methionyl-tRNA synthetase from escherichia coli complexed with trifluoromethionine
Source: Escherichia coli. Organism_taxid: 562. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (546 residues) CATH domains: 2.20.28.20 3.40.50.620 1.10.730.10
Bound ligand:   Het Group MF3 is 75.00% similar to enzyme reactant L-methionine
1pfy
Methionyl-tRNA synthetase from escherichia coli complexed with methionyl sulphamoyl adenosine
Source: Escherichia coli. Organism_taxid: 562. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (547 residues) CATH domains: 2.20.28.20 3.40.50.620 1.10.730.10
Bound ligand:   Het Group MSP is 54.00% similar to enzyme product AMP
1pg0
Methionyl-tRNA synthetase from escherichia coli complexed with methioninyl adenylate
Source: Escherichia coli. Organism_taxid: 562. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (492 residues) CATH domains: 3.40.50.620 1.10.730.10
Bound ligand:   Het Group MOD is 76.00% similar to enzyme product AMP
1pg2
Methionyl-tRNA synthetase from escherichia coli complexed with methionine and adenosine
Source: Escherichia coli. Organism_taxid: 562. Gene: metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (488 residues) CATH domains: 3.40.50.620 1.10.730.10
Bound ligands:   Het Group MET corresponds to enzyme reactant L-methionine
  Het Group ADN is 82.00% similar to enzyme product AMP
1qqt
Methionyl-tRNA synthetase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (546 residues) CATH domains: 2.20.28.20 3.40.50.620 1.10.730.10
1rqg
Methionyl-tRNA synthetase from pyrococcus abyssi
Source: Pyrococcus abyssi. Organism_taxid: 29292. Gene: metg, mets, pyrab09870, pab2364. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (606 residues) CATH domains: 3.40.50.620 2.170.220.10 Unassigned 1.10.730.10
1woy
Crystal structure of methionyl tRNA synthetase y225f mutant from thermus thermophilus
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (500 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
2csx
Crystal structure of aquifex aeolicus methionyl-tRNA synthetase complexed with tRNA(met)
Source: Synthetic: yes. Aquifex aeolicus. Organism_taxid: 63363. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (464 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
2ct8
Crystal structure of aquifex aeolicus methionyl-tRNA synthetase complexed with tRNA(met) and methionyl-adenylate anologue
Source: Synthetic: yes. Aquifex aeolicus. Organism_taxid: 63363. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (465 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MSP is 54.00% similar to enzyme product AMP
2d54
Crystal structure of methionyl tRNA synthetase y225a mutant from thermus thermophilus
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (500 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
2d5b
Crystal structure of thermus thermophilus methionyl tRNA synthetase y225f mutant obtained in the presence of peg6000
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (500 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
2djv
Solution structures of the whep-trs domain of human methionyl-tRNA synthetase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mars. Expressed in: cell free synthesis. Other_details: cell-free protein synthesis
Chain: A (79 residues) CATH domain: Unassigned
2hsn
Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub- complexes
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: mes1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: arc1.
Chain: A (160 residues) CATH domains: Unassigned Unassigned
2x1l
Crystal structure of mycobacterium smegmatis methionyl-tRNA synthetase in complex with methionine and adenosine
Source: Mycobacterium smegmatis. Organism_taxid: 246196. Strain: mc2 155. Atcc: 700084. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (511 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligands:   Het Group MET corresponds to enzyme reactant L-methionine
  Het Group ADN is 82.00% similar to enzyme product AMP
  Het Group 2HP is 55.00% similar to enzyme product diphosphate
2x1m
Crystal structure of mycobacterium smegmatis methionyl-tRNA synthetase in complex with methionine
Source: Mycobacterium smegmatis. Organism_taxid: 246196. Strain: mc2 155. Atcc: 700084. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (511 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligands:   Het Group MET corresponds to enzyme reactant L-methionine
  Het Group 2HP is 55.00% similar to enzyme product diphosphate
3h97
Structure of a mutant methionyl-tRNA synthetase with modifie specificity
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b2114, jw2101, metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (544 residues) CATH domains: 3.40.50.620 2.20.28.20 1.10.730.10
3h99
Structure of a mutant methionyl-tRNA synthetase with modifie specificity complexed with methionine
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b2114, jw2101, metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (544 residues) CATH domains: 3.40.50.620 2.20.28.20 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
3h9b
Structure of a mutant methionyl-tRNA synthetase with modifie specificity complexed with azidonorleucine
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b2114, jw2101, metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (544 residues) CATH domains: 3.40.50.620 2.20.28.20 1.10.730.10
Bound ligand:   Het Group NOT is 50.00% similar to enzyme reactant L-methionine
3h9c
Structure of methionyl-tRNA synthetase: crystal form 2
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b2114, jw2101, metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (544 residues) CATH domains: 3.40.50.620 2.20.28.20 1.10.730.10
3kfl
Leishmania major methionyl-tRNA synthetase in complex with methionyladenylate and pyrophosphate
Source: Leishmania major. Organism_taxid: 5664. Gene: lmjf21.0810, metrs. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (530 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligands:   Het Group ME8 is 74.19% similar to enzyme product AMP
  Het Group POP corresponds to enzyme product diphosphate
3tun
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1356
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
3u1e
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1387
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
3u1f
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1392
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
3u1g
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1415
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (527 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
3u1z
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1433
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (523 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
3u20
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1444
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (530 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
3vu8
Metionyl-tRNA synthetase from thermus thermophilus complexed methionyl-adenylate analogue
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: mets. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (500 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MDS is 72.73% similar to enzyme reactant L-methionine
4bjv
Crystal structure of the aimp3-mrs n-terminal domain complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta2.
Chain: A (211 residues) CATH domains: 3.40.30.10 1.20.1050.10
4bjw
Crystal structure of the aimp3-mrs n-terminal domain complex with i3c
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (203 residues) CATH domains: 3.40.30.10 1.20.1050.10
4bl7
Crystal structure of the aimp3-mrs n-terminal domain complex in different space group
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta2.
Chain: A (208 residues) CATH domains: 3.40.30.10 1.20.1050.10
4bvx
Crystal structure of the aimp3-mrs n-terminal domain complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (203 residues) CATH domains: 3.40.30.10 1.20.1050.10
4bvy
Crystal structure of the aimp3-mrs n-terminal domain complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chain: A (211 residues) CATH domains: 3.40.30.10 1.20.1050.10
4dlp
Crystal structure of methionyl-tRNA synthetase metrs from br melitensis bound to selenomethionine
Source: Brucella melitensis biovar abortus 230 organism_taxid: 359391. Gene: bab1_1014, metg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (493 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MSE is 63.64% similar to enzyme reactant L-methionine
4eg1
Trypanosoma brucei methionyl-tRNA synthetase in complex with methionine
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (529 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4eg3
Trypanosoma brucei methionyl-tRNA synthetase in complex with methionyl-adenylate
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (527 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group ME8 is 74.19% similar to enzyme product AMP
4eg4
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1289
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (522 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4eg5
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1312
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (521 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4eg6
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1325
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (526 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4eg7
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1331
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4eg8
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 89
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligands:   Het Group MET corresponds to enzyme reactant L-methionine
  Het Group 0P6 is 45.83% similar to enzyme product AMP
4ega
Trypanosoma brucei methionyl-tRNA synthetase in complex with chem 1320
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (524 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4lne
Crystal structure of metrs in complex with 2-({3-[(3,5- dichlorobenzyl)amino]propyl}amino)quinolin-4(1h)-one
Source: Brucella melitensis biovar abortus. Organism_taxid: 359391. Strain: 2308. Gene: bab1_1014, metg. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (496 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
4mvw
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea 1433)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (523 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mvx
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-phenylurea (chem
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mvy
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-(3-hydroxyphenyl) 1387)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mw0
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-(2-hydroxyphenyl) 1392)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mw1
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-{3-[(3-chloro-5-methoxybenzyl)amino]propyl}-3-thiophen-3- (chem 1444)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (530 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mw2
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-(3-{[5-chloro-2-hydroxy-3-(prop-2-en-1-yl)benzyl]amino}pr thiophen-3-ylurea (chem 1472)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (521 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mw4
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-{3-[(5-chloro-2-hydroxy-3-iodobenzyl)amino]propyl}-3-thio ylurea (chem 1473)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (523 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mw5
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-{3-[(3-chloro-5-methoxybenzyl)amino]propyl}-3-phenylurea 1415)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (527 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mw6
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-(3-{[2-(benzyloxy)-5-chloro-3-(prop-2-en-1-yl)benzyl]amin 3-thiophen-3-ylurea (chem 1476)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mw7
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-{3-[(5-chloro-2-ethoxy-3-iodobenzyl)amino]propyl}-3-thiop ylurea (chem 1469)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (520 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mw9
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-{3-[(3-ethynylbenzyl)amino]propyl}-3-thiophen-3-ylurea (c
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mwb
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-(3-{[(2,5-dichlorothiophen-3-yl)methyl]amino}propyl)-3-th ylurea (chem 1509)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mwc
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-(3-{[(2-methyl-1-benzothiophen-3-yl)methyl]amino}propyl)- thiophen-3-ylurea (chem 1540)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4mwd
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea 1433) and atp analog amppcp
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (531 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligands:   Het Group MET corresponds to enzyme reactant L-methionine
  Het Group ACP is 74.19% similar to enzyme product AMP
4mwe
Trypanosoma brucei methionyl-tRNA synthetase in complex with 1-(3-{[5-chloro-3-(prop-2-en-1-yl)-2-(prop-2-en-1-yloxy) benzyl]amino}propyl)-3-thiophen-3-ylurea (chem 1475)
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.6470. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (526 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10
Bound ligand:   Het Group MET corresponds to enzyme reactant L-methionine
4ppw
Crystal structure of methionyl-tRNA synthetase metrs from br melitensis in complex with inhibitor chem 1415
Source: Brucella melitensis. Brucella abortus. Organism_taxid: 359391. Strain: 2308. Gene: metg, bab1_1014. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (496 residues) CATH domains: 3.40.50.620 2.170.220.10 1.10.730.10