_EC 5.5.1.8 (+)-bornyl diphosphate synthase. 7 PDB entries  
EC 5.-.-.- Isomerases. [2,271 PDB entries]
EC 5.5.-.- Intramolecular lyases. [59 PDB entries]
EC 5.5.1.- Intramolecular lyases. [59 PDB entries]
EC 5.5.1.8 (+)-bornyl diphosphate synthase. [7 PDB entries]    
1n1b

Pathway: Monoterpenoid Biosynthesis
Reaction: Geranyl diphosphate = (+)-bornyl diphosphate.
 


Geranyl diphosphate
=
(+)-bornyl diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Bornyl pyrophosphate synthase. Bornyl pyrophosphate synthetase. Geranyl-diphosphate cyclase.
Comments: The enzyme from Salvia officinalis (sage) can also use (3R)-linalyl diphosphate or more slowly neryl diphosphate in vitro. The reaction proceeds via isomeration of geranyl diphosphate to (3R)- linalyl diphosphate. The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (+)-bornyl diphosphate. cf. Ec 5.5.1.22.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.5.5.1.8

  PDB code Protein
1n1b
Crystal structure of (+)-bornyl diphosphate synthase from sage
Source: Salvia officinalis. Garden sage. Organism_taxid: 38868. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (516 residues) CATH domains: 1.50.10.130 1.10.600.10
1n1z
(+)-Bornyl diphosphate synthase: complex with mg and pyrophosphate
Source: Salvia officinalis. Garden sage. Organism_taxid: 38868. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (537 residues) CATH domains: 1.50.10.130 1.10.600.10
1n20
(+)-Bornyl diphosphate synthase: complex with mg and 3-aza- 2,3-dihydrogeranyl diphosphate
Source: Salvia officinalis. Garden sage. Organism_taxid: 38868. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (532 residues) CATH domains: 1.50.10.130 1.10.600.10
1n21
(+)-Bornyl diphosphate synthase: cocrystal with mg and 3- aza-2,3-dihydrogeranyl diphosphate
Source: Salvia officinalis. Garden sage. Organism_taxid: 38868. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (535 residues) CATH domains: 1.50.10.130 1.10.600.10
1n22
(+)-Bornyl diphosphate synthase: complex with mg, pyrophosphate, and (4r)-7-aza-7,8-dihydrolimonene
Source: Salvia officinalis. Garden sage. Organism_taxid: 38868. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (534 residues) CATH domains: 1.50.10.130 1.10.600.10
1n23
(+)-Bornyl diphosphate synthase: complex with mg, pyrophosphate, and (1r,4s)-2-azabornane
Source: Salvia officinalis. Garden sage. Organism_taxid: 38868. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (533 residues) CATH domains: 1.50.10.130 1.10.600.10
1n24
(+)-Bornyl diphosphate synthase: complex with mg and product
Source: Salvia officinalis. Garden sage. Organism_taxid: 38868. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (534 residues) CATH domains: 1.50.10.130 1.10.600.10