_EC 5.4.4.2 Isochorismate synthase. 14 PDB entries  
EC 5.-.-.- Isomerases. [2,272 PDB entries]
EC 5.4.-.- Intramolecular transferases (mutases). [417 PDB entries]
EC 5.4.4.- Transferring hydroxy groups. [14 PDB entries]
EC 5.4.4.2 Isochorismate synthase. [14 PDB entries]    
2eua

Pathway: Shikimate and Chorismate Biosynthesis
Reaction: Chorismate = isochorismate.
 


Chorismate
=
isochorismate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Isochorismate mutase. Isochorismate synthetase.
Cofactor(s): Mg(2+).
Comments: The reaction is reversible. Formerly Ec 5.4.99.6.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 14 PDB entries in enzyme class E.C.5.4.4.2

  PDB code Protein
2eua
Structure and mechanism of menf, the menaquinone-specific isochorismate synthase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Gene: menf. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (428 residues) CATH domain: 3.60.120.10
Bound ligand:   Het Group TAR is 44.00% similar to enzyme product Isochorismate
2g5f
The structure of mbti from mycobacterium tuberculosis, the f enzyme in the synthesis of mycobactin, reveals it to be a s synthase
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: mbti. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (435 residues) CATH domain: 3.60.120.10
2i6y
Structure and mechanism of mycobacterium tuberculosis salicy synthase, mbti
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: mbti, mt2454, rv2386c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (419 residues) CATH domain: 3.60.120.10
3bzm
Crystal structure of open form of menaquinone-specific isochorismate synthase, menf
Source: Escherichia coli. Gene: menf, yfba. Expressed in: escherichia coli.
Chain: A (429 residues) CATH domain: 3.60.120.10
Bound ligand:   Het Group CIT is 45.00% similar to enzyme reactant Chorismate
3bzn
Crystal structure of open form of menaquinone-specific isochorismate synthase, menf
Source: Escherichia coli. Gene: menf, yfba. Expressed in: escherichia coli.
Chain: A (430 residues) CATH domain: 3.60.120.10
3hwo
Crystal structure of escherichia coli enterobactin-specific isochorismate synthase entc in complex with isochorismate
Source: Escherichia coli. Organism_taxid: 83333. Gene: b0593, entc, jw0585. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (379 residues) CATH domain: 3.60.120.10
Bound ligand:   Het Group ISC corresponds to enzyme product Isochorismate
3log
Crystal structure of mbti from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: mbti, mt2454, rv2386c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (435 residues) CATH domain: 3.60.120.10
3os6
Crystal structure of putative 2,3-dihydroxybenzoate-specific isochorismate synthase, dhbc from bacillus anthracis.
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 198094. Strain: ames. Gene: bas2205, ba_2369, dhbc, gbaa2369, gbaa_2369. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (373 residues) CATH domain: 3.60.120.10
3rv6
Structure of a m. Tuberculosis salicylate synthase, mbti, in with an inhibitor with phenyl r-group
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2386c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (417 residues) CATH domain: 3.60.120.10
3rv7
Structure of a m. Tuberculosis salicylate synthase, mbti, in with an inhibitor with isopropyl r-group
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2386c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (416 residues) CATH domain: 3.60.120.10
3rv8
Structure of a m. Tuberculosis salicylate synthase, mbti, in with an inhibitor with cyclopropyl r-group
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2386c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (418 residues) CATH domain: 3.60.120.10
3rv9
Structure of a m. Tuberculosis salicylate synthase, mbti, in with an inhibitor with ethyl r-group
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2386c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (420 residues) CATH domain: 3.60.120.10
3st6
Structure of a m. Tuberculosis synthase, mbti, in complex wi isochorismate analogue inhibitor
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2386c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (436 residues) CATH domain: 3.60.120.10
3veh
Structure of a m. Tuberculosis salicylate synthase, mbti, in with an inhibitor methylamt
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: mbti, trpe2, rv2386c, mt2454. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (435 residues) CATH domain: 3.60.120.10
Bound ligand:   Het Group 0GA is 94.12% similar to enzyme product Isochorismate