_EC 5.4.3.8 Glutamate-1-semialdehyde 2,1-aminomutase. 21 PDB entries  
EC 5.-.-.- Isomerases. [2,271 PDB entries]
EC 5.4.-.- Intramolecular transferases (mutases). [417 PDB entries]
EC 5.4.3.- Transferring amino groups. [44 PDB entries]
EC 5.4.3.8 Glutamate-1-semialdehyde 2,1-aminomutase. [21 PDB entries]    
2cfb

Pathway: Porphyrin Biosynthesis (early stages)
Reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.
 


(S)-4-amino-5-oxopentanoate
=
5-aminolevulinate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Glutamate-1-semialdehyde aminotransferase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 21 PDB entries in enzyme class E.C.5.4.3.8

  PDB code Protein
2cfb
Glutamate-1-semialdehyde 2,1-aminomutase from thermosynechococcus elongatus
Source: Synechococcus elongatus. Organism_taxid: 32046. Strain: bp-1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (360 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLR is 50.00% similar to enzyme product 5-aminolevulinate
2e7u
Crystal structure of glutamate-1-semialdehyde 2,1-aminomutas thermus thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (424 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PMP is 47.06% similar to enzyme product 5-aminolevulinate
2epj
Crystal structure of glutamate-1-semialdehyde 2,1-aminomutas aeropyrum pernix
Source: Aeropyrum pernix. Organism_taxid: 272557. Strain: k1. Gene: heml. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (420 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PMP is 47.06% similar to enzyme product 5-aminolevulinate
2gsa
Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form)
Source: Synechococcus sp.. Organism_taxid: 1131. Strain: gr6. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PMP is 47.06% similar to enzyme product 5-aminolevulinate
2hoy
Inter-subunit signaling in gsam
Source: Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Gene: heml, gsa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (402 residues) CATH domains: 3.90.1150.10 3.40.640.10
2hoz
Inter-subunit signaling in gsam
Source: Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Gene: heml, gsa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group HOZ is 80.00% similar to enzyme reactant L-glutamate
  Het Group PMP is 47.06% similar to enzyme product 5-aminolevulinate
2hp1
Inter-subunit signaling in gsam
Source: Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Gene: heml, gsa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group HOZ is 80.00% similar to enzyme reactant L-glutamate
  Het Group PLP is 50.00% similar to enzyme product 5-aminolevulinate
2hp2
Inter-subunit signaling in gsam
Source: Synechococcus elongatus. Organism_taxid: 269084. Strain: pcc 6301. Gene: heml, gsa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group HOZ is 80.00% similar to enzyme reactant L-glutamate
  Het Group PLP is 50.00% similar to enzyme product 5-aminolevulinate
2zsl
Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase from aeropyrum pernix
Source: Aeropyrum pernix. Organism_taxid: 56636. Strain: k1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (420 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PMP is 47.00% similar to enzyme product 5-aminolevulinate
2zsm
Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase from aeropyrum pernix, hexagonal form
Source: Aeropyrum pernix. Organism_taxid: 56636. Strain: k1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (425 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PMP is 47.00% similar to enzyme product 5-aminolevulinate
3bs8
Crystal structure of glutamate 1-semialdehyde aminotransfera complexed with pyridoxamine-5'-phosphate from bacillus subt
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (430 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PMP is 47.00% similar to enzyme product 5-aminolevulinate
3fq7
Gabaculine complex of gsam
Source: Synechococcus elongatus pcc 6301. Organism_taxid: 269084
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
3fq8
M248i mutant of gsam
Source: Synechococcus elongatus pcc 6301. Organism_taxid: 269084. Gene: heml, gsa, syc0881_c. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: k74.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PMP is 47.00% similar to enzyme product 5-aminolevulinate
3fqa
Gabaculien complex of gabaculine resistant gsam version
Source: Synechococcus elongatus pcc 6301. Organism_taxid: 269084. Gene: heml, gsa, syc0881_c. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: k74.
Chains: A, B (426 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group GAB is 72.00% similar to enzyme reactant L-glutamate 1-semialdehyde
  Het Group PMP is 47.00% similar to enzyme product 5-aminolevulinate
3gsa
Crystal structure of glutamate-1-semialdehyde aminomutase in complex with gabaculine
Source: Synechococcus sp.. Strain: gr6. Expressed in: escherichia coli.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group GAB is 72.00% similar to enzyme reactant (S)-4-amino-5-oxopentanoate
  Het Group PLP is 47.00% similar to enzyme product 5-aminolevulinate
3gsb
Crystal structure of glutamate-1-semialdehyde aminomutase in complex with gabaculine
Source: Synechococcus sp.. Organism_taxid: 1131. Strain: gr6. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group GAB is 72.00% similar to enzyme reactant L-glutamate 1-semialdehyde
  Het Group PMP is 47.00% similar to enzyme product 5-aminolevulinate
3k28
Crystal structure of a glutamate-1-semialdehyde aminotransferase from bacillus anthracis with bound pyridoxal 5'phosphate
Source: Bacillus anthracis str. 'Ames ancestor'. Anthrax,anthrax bacterium. Organism_taxid: 261594. Strain: ames ancestor. Gene: bas4358, ba_4693, gbaa_4693, heml-2, heml2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (423 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 50.00% similar to enzyme product 5-aminolevulinate
3l44
Crystal structure of bacillus anthracis heml-1, glutamate se aminotransferase
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 261594. Strain: ames ancestor. Gene: heml1, ba_0531, gbaa_0531, bas0499. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (426 residues) CATH domains: 3.90.1150.10 3.40.640.10
3usf
Crystal structure of dava-4
Source: Synechococcus elongatus. Organism_taxid: 1140. Strain: pcc 7942. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
4e77
2.0a crystal structure of a glutamate-1-semialdehyde aminotr from yersinia pestis co92
Source: Yersinia pestis. Organism_taxid: 386656. Strain: co92. Gene: heml, ypdsf_2968. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (406 residues) CATH domains: 3.90.1150.10 3.40.640.10
4gsa
Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase) reduced with cyanoborohydrate
Source: Synechococcus sp.. Organism_taxid: 1131. Strain: gr6. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 50.00% similar to enzyme product 5-aminolevulinate