_EC 5.4.2.8 Phosphomannomutase. 23 PDB entries  
EC 5.-.-.- Isomerases. [2,272 PDB entries]
EC 5.4.-.- Intramolecular transferases (mutases). [417 PDB entries]
EC 5.4.2.- Phosphotransferases (phosphomutases). [162 PDB entries]
EC 5.4.2.8 Phosphomannomutase. [23 PDB entries]    
1k2y

Pathway: GDP-L-Fucose and GDP-mannose Biosynthesis
Reaction: Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
 


Alpha-D-mannose 1-phosphate
=
D-mannose 6-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Phosphomannose mutase.
Comments: Alpha-D-mannose 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate can act as cofactor. Formerly Ec 2.7.5.7.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 23 PDB entries in enzyme class E.C.5.4.2.8

  PDB code Protein
1k2y
Crystal structure of phosphomannomutase/phosphoglucomutase s108a mutant from p. Aeruginosa
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: X (459 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
Bound ligand:   Het Group TLA is 52.00% similar to enzyme reactant alpha-D-mannose 1-phosphate
1k35
Crystal structure of phosphomannomutase/phosphoglucomutase from p.Aeruginosa
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (455 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
1lll
Structure of phosphomannomutase-salmonella typhimurium
Source: Salmonella typhimurium. Bacteria
Chain: A (456 residues)
1p5d
Enzyme-ligand complex of p. Aeruginosa pmm/pgm
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc or pa5322. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: X (455 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
Bound ligand:   Het Group G1P corresponds to enzyme reactant alpha-D-mannose
1p5g
Enzyme-ligand complex of p. Aeruginosa pmm/pgm
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc or pa5322. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (455 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
Bound ligand:   Het Group G6P corresponds to enzyme reactant alpha-D-mannose
1pcj
Enzyme-ligand complex of p. Aeruginosa pmm/pgm
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc or pa5322. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (458 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
Bound ligand:   Het Group M1P corresponds to enzyme reactant alpha-D-mannose
1pcm
Enzyme-ligand complex of p. Aeruginosa pmm/pgm
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc or pa5322. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (455 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
Bound ligand:   Het Group M6P corresponds to enzyme reactant alpha-D-mannose
2amy
X-ray structure of human phosphomannomutase 2 (pmm2)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hs.459855. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (240 residues) CATH domain: 3.40.50.1000
2fkf
Phosphomannomutase/phosphoglucomutase from pseudomonas aerug alpha-d-glucose 1,6-bisphosphate bound
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (455 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
Bound ligand:   Het Group G16 is 80.00% similar to enzyme reactant alpha-D-mannose
2fkm
Pmm/pgm s108d mutant with alpha-d-glucose 1,6-bisphosphate b
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: X (454 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
Bound ligand:   Het Group G16 is 80.00% similar to enzyme reactant alpha-D-mannose
2fuc
Human alpha-phosphomannomutase 1 with mg2+ cofactor bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (245 residues) CATH domain: 3.40.50.1000
2fue
Human alpha-phosphomannomutase 1 with d-mannose 1-phosphate cofactor bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (246 residues) CATH domain: 3.40.50.1000
Bound ligand:   Het Group M1P corresponds to enzyme reactant alpha-D-mannose
2h4l
Complex of pmm/pgm with ribose 1-phosphate
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: X (455 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
Bound ligand:   Het Group R1P is 87.50% similar to enzyme reactant alpha-D-mannose
2h5a
Complex of the enzyme pmm/pgm with xylose 1-phosphate
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: X (455 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
Bound ligand:   Het Group X1P is 87.50% similar to enzyme reactant alpha-D-mannose
2i54
Phosphomannomutase from leishmania mexicana
Source: Leishmania mexicana. Organism_taxid: 5665. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (242 residues) CATH domain: 3.40.50.1000
2i55
Complex of glucose-1,6-bisphosphate with phosphomannomutase leishmania mexicana
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: m379. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (242 residues) CATH domain: 3.40.50.1000
Bound ligand:   Het Group B16 is 80.00% similar to enzyme reactant alpha-D-mannose
2q4r
Ensemble refinement of the protein crystal structure of huma phosphomannomutase 2 (pmm2)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pmm2, hs.459855. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (240 residues) CATH domain: 3.40.50.1000
3bkq
Structure of the p368g mutant of pmm/pgm in complex with its
Source: Pseudomonas aeruginosa. Strain: pao1. Gene: algc. Expressed in: escherichia coli.
Chain: X (458 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
Bound ligand:   Het Group G1P corresponds to enzyme reactant alpha-D-mannose
3c04
Structure of the p368g mutant of pmm/pgm from p. Aeruginosa
Source: Pseudomonas aeruginosa. Strain: pao1. Gene: algc. Expressed in: escherichia coli.
Chain: A (458 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
3f9r
Crystal structure of trypanosoma brucei phosphomannosemutase, tb.10.700.370
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: tb10.70.0370, tb10.700.370. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (246 residues) CATH domain: 3.40.50.1000
3rsm
Crystal structure of s108c mutant of pmm/pgm
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: algc, pa5322. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (436 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
4il8
Crystal structure of an h329a mutant of p. Aeruginosa pmm/pg
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: atcc 15692 / pao1 / 1c / prs 101 / lmg 12228. Gene: algc, pa5322. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (459 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50
4mrq
Crystal structure of wild-type unphosphorylated pmm/pgm
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: atcc 15692 / pao1 / 1c / prs 101 / lmg 12228. Gene: algc, pa5322. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (455 residues) CATH domains: 3.40.120.10 3.40.120.10 3.40.120.10 3.30.310.50