_EC 5.4.2.6 Beta-phosphoglucomutase. 18 PDB entries  
EC 5.-.-.- Isomerases. [2,266 PDB entries]
EC 5.4.-.- Intramolecular transferases (mutases). [410 PDB entries]
EC 5.4.2.- Phosphotransferases (phosphomutases). [159 PDB entries]
EC 5.4.2.6 Beta-phosphoglucomutase. [18 PDB entries]    
1lvh

Pathway: b-phosphoglucomutase
Reaction: Beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate.
 


Beta-D-glucose 1-phosphate
=
beta-D-glucose 6-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: The enzyme is able to autophosphorylate itself with its substrate beta-D-glucose 1-phosphate. Although this is a slow reaction, only a single turnover is required for activation. Once the phosphorylated enzyme is formed, it generates the reaction intermediate beta-D-glucose 1,6-bisphosphate, which can be used to phosphorylate the enzyme in subsequent cycles. Cf. Ec 5.4.2.2.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 18 PDB entries in enzyme class E.C.5.4.2.6

  PDB code Protein
1lvh
The structure of phosphorylated beta-phosphoglucomutase from lactoccocus lactis to 2.3 angstrom resolution
Source: Lactococcus lactis. Organism_taxid: 1358. Gene: pgmb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (221 residues) CATH domains: 3.40.50.1000 1.10.150.240
1o03
Structure of pentavalent phosphorous intermediate of an enzyme catalyzed phosphoryl transfer reaction observed on cocrystallization with glucose 6-phosphate
Source: Lactococcus lactis. Organism_taxid: 1358. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (221 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group G16 is 80.00% similar to enzyme reactant beta-D-glucose 1-phosphate
1o08
Structure of pentavalent phosphorous intermediate of an enzyme catalyzed phosphoryl transfer reaction observed on cocrystallization with glucose 1-phosphate
Source: Lactococcus lactis. Organism_taxid: 1358. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (221 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group G16 is 80.00% similar to enzyme reactant beta-D-glucose 1-phosphate
1z4n
Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with fluoride
Source: Lactococcus lactis. Organism_taxid: 1358. Gene: pgmb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (219 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group GL1 corresponds to enzyme reactant beta-D-glucose 1-phosphate
1z4o
Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate
Source: Lactococcus lactis. Organism_taxid: 1358. Gene: pgmb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (219 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group GL1 corresponds to enzyme reactant beta-D-glucose 1-phosphate
1zol
Native beta-pgm
Source: Lactococcus lactis. Organism_taxid: 1358. Gene: ll0429. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (221 residues) CATH domains: 3.40.50.1000 1.10.150.240
2wf5
Structure of beta-phosphoglucomutase inhibited with glucose- 6-phospahte and trifluoromagnesate
Source: Lactococcus lactis. Organism_taxid: 1358. Strain: 19435. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (218 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group BG6 corresponds to enzyme product beta-D-glucose 6-phosphate
2wf6
Structure of beta-phosphoglucomutase inhibited with glucose- 6-phospahte and aluminium tetrafluoride
Source: Lactococcus lactis. Organism_taxid: 1358. Strain: 19435. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (218 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group BG6 corresponds to enzyme product beta-D-glucose 6-phosphate
2wf7
Structure of beta-phosphoglucomutase inhibited with glucose- 6-phosphonate and aluminium tetrafluoride
Source: Lactococcus lactis. Organism_taxid: 1358. Strain: 19435. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (218 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group G7P is 52.00% similar to enzyme reactant beta-D-glucose 1-phosphate
2wf8
Structure of beta-phosphoglucomutase inhibited with glucose- 6-phosphate, glucose-1-phosphate and beryllium trifluoride
Source: Lactococcus lactis. Organism_taxid: 1358. Strain: 19435. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (218 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group G1P corresponds to enzyme reactant beta-D-glucose
2wf9
Structure of beta-phosphoglucomutase inhibited with glucose- 6-phosphate, and beryllium trifluoride, crystal form 2
Source: Lactococcus lactis. Organism_taxid: 1358. Strain: 19435. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (221 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group G6P corresponds to enzyme reactant beta-D-glucose
2wfa
Structure of beta-phosphoglucomutase inhibited with beryllium trifluoride, in an open conformation.
Source: Lactococcus lactis. Organism_taxid: 1358. Strain: 19435. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (221 residues) CATH domains: 3.40.50.1000 1.10.150.240
2whe
Structure of native beta-phosphoglucomutase in an open conformation without bound ligands.
Source: Lactococcus lactis. Organism_taxid: 1358. Strain: 19435. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (221 residues) CATH domains: 3.40.50.1000 1.10.150.240
3fm9
Analysis of the structural determinants underlying discrimination between substrate and solvent in beta- phosphoglucomutase catalysis
Source: Lactococcus lactis subsp. Lactis. Streptococcus lactis. Organism_taxid: 1360. Gene: l0001, ll0429, pgmb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (220 residues) CATH domains: 3.40.50.1000 1.10.150.240
3nas
The crystal structure of beta-phosphoglucomutase from bacill subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Gene: bsu34550, yvdm. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (207 residues) CATH domains: 3.40.50.1000 1.10.150.240
3zi4
The structure of beta-phosphoglucomutase inhibited with glucose-6-phospahte and scandium tetrafluoride
Source: Lactococcus lactis. Organism_taxid: 1358. Strain: 19435. Atcc: 1358. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (218 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group BG6 corresponds to enzyme product beta-D-glucose
4g9b
Crystal structure of beta-phosphoglucomutase homolog from es coli, target efi-501172, with bound mg, open lid
Source: Escherichia coli. Organism_taxid: 83333. Strain: str. K-12 substr. Mg1655. Gene: ycju, b1317, jw1310. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (227 residues) CATH domains: 3.40.50.1000 1.10.150.240
Bound ligand:   Het Group UNL is 47.06% similar to enzyme reactant beta-D-glucose
4gib
2.27 angstrom crystal structure of beta-phosphoglucomutase ( clostridium difficile
Source: Clostridium difficile. Organism_taxid: 272563. Strain: 630. Gene: cd630_21890, pgmb. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (225 residues) CATH domains: 3.40.50.1000 1.10.150.240