_EC 5.4.2.4 Bisphosphoglycerate mutase. 13 PDB entries  
EC 5.-.-.- Isomerases. [2,400 PDB entries]
EC 5.4.-.- Intramolecular transferases (mutases). [435 PDB entries]
EC 5.4.2.- Phosphotransferases (phosphomutases). [162 PDB entries]
EC 5.4.2.4 Bisphosphoglycerate mutase. [13 PDB entries]    
1t8p

Reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.
 


3-phospho-D-glyceroyl phosphate
=
2,3-bisphospho-D-glycerate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 2,3-bisphosphoglycerate mutase. 2,3-bisphosphoglycerate synthase. 2,3-diphosphoglycerate mutase. Bisphosphoglycerate synthase. Bpgm. Diphosphoglycerate mutase. Diphosphoglyceromutase. Glycerate phosphomutase.
Comments: In the direction shown, the enzyme is phosphorylated by 3-phosphoglyceroyl phosphate to give phosphoenzyme and 3-phosphoglycerate. The latter is rephosphorylated by the enzyme to yield 2,3- diphosphoglycerate, but this reaction is slowed down by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate. Also catalyzes, slowly, the reactions of Ec 3.1.3.13 and Ec 5.4.2.12. Formerly Ec 2.7.5.4.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 13 PDB entries in enzyme class E.C.5.4.2.4

  PDB code Protein
1t8p
Crystal structure of human erythrocyte 2,3- bisphosphoglycerate mutase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (249 residues) CATH domain: 3.40.50.1240
1yfk
Crystal structure of human b type phosphoglycerate mutase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (243 residues) CATH domain: 3.40.50.1240
1yjx
Crystal structure of human b type phosphoglycerate mutase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (245 residues) CATH domain: 3.40.50.1240
2a9j
Human bisphosphoglycerate mutase complexed with 3- phosphoglycerate (17 days)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (253 residues) CATH domain: 3.40.50.1240
Bound ligand:   Het Group 3PG is 73.00% similar to enzyme reactant 3-phospho-D-glyceroyl phosphate
2f90
Crystal structure of bisphosphoglycerate mutase in complex with 3-phosphoglycerate and alf4-
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (254 residues) CATH domain: 3.40.50.1240
Bound ligand:   Het Group 3PG is 73.00% similar to enzyme reactant 3-phospho-D-glyceroyl phosphate
2h4x
Human bisphosphoglycerate mutase complex with 3- phosphoglycerate with crystal growth 90 days
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (255 residues) CATH domain: 3.40.50.1240
Bound ligand:   Het Group 3PG is 73.00% similar to enzyme reactant 3-phospho-D-glyceroyl phosphate
2h4z
Human bisphosphoglycerate mutase complexed with 2,3- bisphosphoglycerate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (255 residues) CATH domain: 3.40.50.1240
Bound ligand:   Het Group DG2 corresponds to enzyme product 2,3-bisphospho-D-glycerate
2h52
Crystal structure of human bisphosphoglycerate mutase complex with 3-phosphoglycerate (18 days)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (255 residues) CATH domain: 3.40.50.1240
Bound ligand:   Het Group 3PG is 73.00% similar to enzyme reactant 3-phospho-D-glyceroyl phosphate
2hhj
Human bisphosphoglycerate mutase complexed with 2,3- bisphosphoglycerate (15 days)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (255 residues) CATH domain: 3.40.50.1240
Bound ligand:   Het Group DG2 corresponds to enzyme product 2,3-bisphospho-D-glycerate
3nfy
The structure of human bisphosphoglycerate mutase to 1.94a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bpgm. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (249 residues) CATH domain: 3.40.50.1240
4gpi
Crystal structure of human b type phosphoglycerate mutase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pgam1, pgama, cdabp0006. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: B, C (240 residues) CATH domain: 3.40.50.1240
4gpz
Crystal structure of human b type phosphoglycerate mutase h1 phosphorylated form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pgam1, pgama, cdabp0006. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (242 residues) CATH domain: 3.40.50.1240
4odi
2.6 angstrom crystal structure of putative phosphoglycerate from toxoplasma gondii
Source: Toxoplasma gondii. Organism_taxid: 508771. Strain: me49. Gene: pgmii, tgme49_297060. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, D (246 residues) CATH domain: 3.40.50.1240