_EC 5.3.99.3 Prostaglandin-E synthase. 7 PDB entries  
EC 5.-.-.- Isomerases. [2,271 PDB entries]
EC 5.3.-.- Intramolecular oxidoreductases. [866 PDB entries]
EC 5.3.99.- Other intramolecular oxidoreductases. [52 PDB entries]
EC 5.3.99.3 Prostaglandin-E synthase. [7 PDB entries]    
1ejf

Reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
 

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
=
(5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Endoperoxide isomerase. Pge isomerase. PGH-PGE isomerase. Prostaglandin-H(2) E-isomerase.
Cofactor(s): Glutathione.
 

Glutathione
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Brings about the opening of the epidioxy bridge.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.5.3.99.3

  PDB code Protein
1ejf
Crystal structure of the human co-chaperone p23
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (110 residues) CATH domain: 2.60.40.790
1z9h
Microsomal prostaglandin e synthase type-2
Source: Macaca fascicularis. Crab-eating macaque. Organism_taxid: 9541. Tissue: brain. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (274 residues) CATH domain: 3.40.30.10
2pbj
Gsh-heme bound microsomal prostaglandin e synthase
Source: Macaca fascicularis. Crab-eating macaque. Organism_taxid: 9541. Gene: mpges-2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (274 residues) CATH domain: 3.40.30.10
Bound ligands:   Het Group HEM is 51.00% similar to enzyme product (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
  Het Group GSH corresponds to enzyme cofactor glutathione
3dww
Electron crystallographic structure of human microsomal pros e synthase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (142 residues) CATH domain: 1.20.120.550
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
4al0
Crystal structure of human ps-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chain: A (146 residues) CATH domain: 1.20.120.550
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
4al1
Crystal structure of human ps-1 gsh-analog complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chain: A (143 residues) CATH domain: 1.20.120.550
Bound ligands:   Het Group PLM is 56.00% similar to enzyme product (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
  Het Group 48T is 57.14% similar to enzyme cofactor glutathione
4bpm
Crystal structure of a human integral membrane enzyme
Source: Homo sapiens, synthetic construct. Human. Organism_taxid: 9606, 32630. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (162 residues) CATH domain: 1.20.120.550
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione