_EC 5.3.99.2 Prostaglandin-D synthase. 30 PDB entries  
EC 5.-.-.- Isomerases. [2,252 PDB entries]
EC 5.3.-.- Intramolecular oxidoreductases. [848 PDB entries]
EC 5.3.99.- Other intramolecular oxidoreductases. [52 PDB entries]
EC 5.3.99.2 Prostaglandin-D synthase. [30 PDB entries]    
1iyh

Reaction: (5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.
 

(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
=
(5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): PGD2 synthase. PGH-PGD isomerase. Prostaglandin D synthetase. Prostaglandin D2 synthase. Prostaglandin endoperoxide Delta-isomerase. Prostaglandin-H(2) Delta-isomerase.
Cofactor(s): Glutathione.
 

Glutathione
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Brings about the opening of the epidioxy bridge.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 30 PDB entries in enzyme class E.C.5.3.99.2

  PDB code Protein
1iyh
Crystal structure of hematopoietic prostaglandin d synthase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
1iyi
Crystal structure of hematopoietic prostaglandin d synthase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, D (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
1pd2
Crystal structure of hematopoietic prostaglandin d synthase with glutathione
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: spleen. Cellular_location: cytoplasm. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: de3.
Chains: 1, 2 (199 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
1v40
First inhibitor complex structure of human hematopoietic pro d synthase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
2cvd
Crystal structure analysis of human hematopoietic prostaglan synthase complexed with hql-79
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
2czt
Lipocalin-type prostaglandin d synthase
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (155 residues) CATH domain: 2.40.128.20
2czu
Lipocalin-type prostaglandin d synthase
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (153 residues) CATH domain: 2.40.128.20
2e4j
Solution structure of mouse lipocalin-type prostaglandin d synthase
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (167 residues) CATH domain: 2.40.128.20
2ktd
Solution structure of mouse lipocalin-type prostaglandin d s substrate analog (u-46619) complex
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ptgds. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (167 residues) CATH domain: 2.40.128.20
2rq0
Solution structure of mouse lipocalin-type prostaglandin d synthase possessing the intrinsic disulfide bond
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ptgds. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (167 residues) CATH domain: 2.40.128.20
2vcq
Complex structure of prostaglandin d2 synthase at 1.95a.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, D (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligands:   Het Group D25 is 46.00% similar to enzyme reactant prostaglandin H(2)
  Het Group GSH corresponds to enzyme cofactor glutathione
2vcw
Complex structure of prostaglandin d2 synthase at 1.95a.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
2vcx
Complex structure of prostaglandin d2 synthase at 2.1a.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
2vcz
Complex structure of prostaglandin d2 synthase at 1.95a.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: B, C, D ( residues)
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
2vd0
Complex structure of prostaglandin d2 synthase at 2.2a.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
2vd1
Complex structure of prostaglandin d2 synthase at 2.25a.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, D (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
2wwp
Crystal structure of the human lipocalin-type prostaglandin d synthase crystallised with the substrate analog 9,11-dideoxy-9alpha,11alpha-epoxymethanoprostaglandin f2alpha
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare.
Chains: A, B (150 residues) CATH domain: 2.40.128.20
3ee2
Structure of human prostaglandin d-synthase (hgsts1-1) in co nocodazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pgds. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
3kxo
An orally active inhibitor bound at the active site of hpgds
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptgds2, pgds. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme cofactor glutathione
3o19
Structure-function analysis of human l-prostaglandin d synth with fatty acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptgds, pds. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (154 residues) CATH domain: 2.40.128.20
Bound ligand:   Het Group OLA is 80.00% similar to enzyme reactant prostaglandin H(2)
3o22
Structure-function analysis of human l-prostaglandin d synth with fatty acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptgds, pds. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (157 residues) CATH domain: 2.40.128.20
Bound ligand:   Het Group OLA is 80.00% similar to enzyme reactant prostaglandin H(2)
3o2y
Structure-function analysis of human l-prostaglandin d synth with fatty acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (160 residues) CATH domain: 2.40.128.20
Bound ligand:   Het Group OLA is 80.00% similar to enzyme reactant prostaglandin H(2)
3vi5
Human hematopoietic prostaglandin d synthase inhibitor compl structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hpgds, gsts, pgds, ptgds2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
3vi7
Human hematopoietic prostaglandin d synthase inhibitor compl structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hpgds, gsts, pgds, ptgds2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
4ec0
Crystal structure of hh-pgds with water displacing inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsts, hpgds, pgds, ptgds2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (199 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligands:   Het Group 7PQ is 45.95% similar to enzyme product (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
  Het Group GSH corresponds to enzyme cofactor glutathione
4edy
Crystal structure of hh-pgds with water displacing inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsts, hpgds, pgds, ptgds2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
4edz
Crystal structure of hh-pgds with water displacing inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsts, hpgds, pgds, ptgds2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (198 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligands:   Het Group 0O5 is 43.24% similar to enzyme product (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
  Het Group GSH corresponds to enzyme cofactor glutathione
4ee0
Crystal structure of hh-pgds with water displacing inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsts, hpgds, pgds, ptgds2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (194 residues) CATH domains: 3.40.30.10 1.20.1050.10
4imn
Crystal structure of wild type human lipocalin pgds bound wi 2000
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pds, ptgds. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (154 residues) CATH domain: 2.40.128.20
4imo
Crystal structure of wild type human lipocalin pgds in compl substrate analog u44069
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pds, ptgds. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (155 residues) CATH domain: 2.40.128.20
Bound ligand:   Het Group PWZ is 92.31% similar to enzyme product (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate