_EC 5.3.4.1 Protein disulfide-isomerase. 38 PDB entries  
EC 5.-.-.- Isomerases. [2,272 PDB entries]
EC 5.3.-.- Intramolecular oxidoreductases. [867 PDB entries]
EC 5.3.4.- Transposing S-S bonds. [38 PDB entries]
EC 5.3.4.1 Protein disulfide-isomerase. [38 PDB entries]    
1bjx

Reaction: Catalyzes the rearrangement of -S-S- bonds in proteins.
Other name(s): S-S rearrangase.
Comments: Needs reducing agents or partly reduced enzyme; the reaction depends on sulfhydryl-disulfide interchange.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 38 PDB entries in enzyme class E.C.5.3.4.1

  PDB code Protein
1bjx
Human protein disulfide isomerase, nmr, 24 structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (110 residues) CATH domain: 3.40.30.10
1mek
Human protein disulfide isomerase, nmr, 40 structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (120 residues) CATH domain: 3.40.30.10
1v52
Solution structure of the b' domain of thermophilic fungal protein disulfide isomerase
Source: Humicola insolens. Fungi. Expressed in: escherichia coli.
Chain: A (133 residues) CATH domain: 3.40.30.10
1x5c
The solution structure of the second thioredoxin-like domain of human protein disulfide-isomerase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: p4hb. Other_details: cell-free protein synthesis
Chain: A (121 residues) CATH domain: 3.40.30.10
1x5d
The solution structure of the second thioredoxin-like domain of human protein disulfide-isomerase a6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdia6. Other_details: cell-free protein synthesis
Chain: A (133 residues) CATH domain: 3.40.30.10
1xtx
Solution structure of the a' domain of thermophilic fungal protein disulfide isomerase
Source: Humicola insolens. Fungi. Expressed in: escherichia coli.
Chain: A (121 residues) CATH domain: 3.40.30.10
1y9n
Theoretical model of the protein disulfide isomerase (a- domain) from plasmodium chabaudi
Source: Plasmodium chabaudi. Strain: as
Chain: A (107 residues)
1y9p
Theoretical model of the protein disulfide isomerase (a'- domain) from plasmodium chabaudi
Source: Plasmodium chabaudi. Strain: as
Chain: A (109 residues)
1yk6
Theoretical model of the protein disulfide isomerase from plasmodium chabaudi
Source: Plasmodium chabaudi chabaudi. Strain: as
Chain: A (441 residues)
2alb
Nmr structure of the n-terminal domain a of the glycoprotein chaperone erp57
Source: Synthetic: yes. Other_details: this sequence occurs naturally in humans
Chain: A (113 residues) CATH domain: 3.40.30.10
2b5e
Crystal structure of yeast protein disulfide isomerase
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: pdi1, mfp1, trg1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (483 residues) CATH domains: 3.40.30.10 Unassigned 3.40.30.10 3.40.30.10
2bjx
Protein disulfide isomerase
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21 (de3). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (110 residues) CATH domain: 3.40.30.10
2dj1
The solution structure of the first thioredoxin domain of mouse protein disulfide-isomerase a4
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: pdia4, cai, erp72. Expressed in: cell free synthesis. Other_details: cell-free protein synthesis
Chain: A (140 residues) CATH domain: 3.40.30.10
2dj2
The solution structure of the second thioredoxin domain of mouse protein disulfide-isomerase a4
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: pdia4, cai, erp72. Expressed in: cell free synthesis. Other_details: cell-free protein synthesis
Chain: A (120 residues) CATH domain: 3.40.30.10
2dj3
The solution structure of the third thioredoxin domain of mouse protein disulfide-isomerase a4
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: pdia4, cai, erp72. Expressed in: cell free synthesis. Other_details: cell-free protein synthesis
Chain: A (133 residues) CATH domain: 3.40.30.10
2djj
Solution structure of the a' domain of thermophilic fungal protein disulfide isomerase
Source: Humicola insolens. Organism_taxid: 34413. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (121 residues) CATH domain: 3.40.30.10
2djk
Solution structure of the b' domain of thermophilic fungal protein disulfide isomerase
Source: Humicola insolens. Organism_taxid: 34413. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (133 residues) CATH domain: 3.40.30.10
2dml
The solution structure of the first thioredoxin domain of mouse protein disulfide-isomerase a6
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: pdia6. Expressed in: cell free synthesis. Other_details: cell-free protein synthesis
Chain: A (130 residues) CATH domain: 3.40.30.10
2dmm
The solution structure of the second thioredoxin domain of human protein disulfide-isomerase a3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdia3, erp60, grp58. Expressed in: cell free synthesis. Other_details: cell-free protein synthesis
Chain: A (142 residues) CATH domain: 3.40.30.10
2h8l
Crystal structure of the bb' fragment of erp57
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdia3, erp60, grp58. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (232 residues) CATH domains: 3.40.30.10 3.40.30.10
2k18
Solution structure of bb' domains of human protein disulfide isomerase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: p4hb, erba2l, pdi, pdia1, po4db. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (228 residues) CATH domains: 3.40.30.10 3.40.30.10
2kp1
Solution structure of the a' domain of thermophilic fungal protein disulfide isomerase
Source: Humicola insolens. Organism_taxid: 34413. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: de3.
Chain: A (121 residues) CATH domain: 3.40.30.10
2kp2
Solution structure of the b' domain of thermophilic fungal protein disulfide isomerase
Source: Humicola insolens. Organism_taxid: 34413. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: de3.
Chain: A (133 residues) CATH domain: 3.40.30.10
3bj5
Alternative conformations of the x region of human protein d isomerase modulate exposure of the substrate binding b' dom
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: p4hb, erba2l, pdi, pdia1, po4db. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (130 residues) CATH domain: 3.40.30.10
3boa
Crystal structure of yeast protein disulfide isomerase.
Source: Saccharomyces cerevisiae. Baker's yeast. Strain: w303. Gene: pdi1, mfp1, trg1. Expressed in: escherichia coli.
Chain: A (490 residues) CATH domains: 3.40.30.10 Unassigned 3.40.30.10 3.40.30.10
3ec3
Crystal structure of the bb fragment of erp72
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pdia4, cabp2, erp70. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (231 residues) CATH domains: 3.40.30.10 3.40.30.10
3ed3
Crystal structure of the yeast dithiol/disulfide oxidoreductase mpd1p
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: mpd1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (267 residues) CATH domain: 3.40.30.10
3f8u
Tapasin/erp57 heterodimer
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdia3, erp57, erp60, grp58. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: tapbp, ngs17, tapa.
Chains: A, C (469 residues) CATH domains: 3.40.30.10 3.40.30.10 3.40.30.10 3.40.30.10
3idv
Crystal structure of the a0a fragment of erp72
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdia4, erp70, erp72. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (235 residues) CATH domains: 3.40.30.10 3.40.30.10
3uem
Crystal structure of human pdi bb'a' domains
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdi. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (358 residues) CATH domains: 3.40.30.10 3.40.30.10 3.40.30.10
3vww
Crystal structure of a0-domain of p5 from h. Sapiens
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdia6, erp5, p5, txndc7. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (116 residues) CATH domain: 3.40.30.10
3w8j
Crystal structure of p5 a0 in a complex with prx4 c-term
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdia6, erp5, p5, txndc7. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Mus musculus. Mouse.
Chains: A, B (121 residues) CATH domain: 3.40.30.10
4ef0
Crystal structure of the first catalytic domain of protein d isomerase p5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdia6, erp5, p5, txndc7. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (115 residues) CATH domain: 3.40.30.10
4ekz
Crystal structure of reduced hpdi (abb'xa')
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: p4hb, erba2l, pdi, pdia1, po4db. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (469 residues) CATH domains: 3.40.30.10 3.40.30.10 3.40.30.10 3.40.30.10
4el1
Crystal structure of oxidized hpdi (abb'xa')
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: p4hb, erba2l, pdi, pdia1, po4db. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (452 residues) CATH domains: 3.40.30.10 3.40.30.10 3.40.30.10 3.40.30.10
4gwr
Crystal structure of the second catalytic domain of protein isomerase p5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdia6, erp5, p5, txndc7. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (112 residues) CATH domain: 3.40.30.10
4i6x
Crystal structure of non-catalyic domain of protein disulfid isomerase-related (pdir) protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdia5, pdir. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (117 residues) CATH domain: 3.40.30.10
4ju5
Crystal structure of the dimeric form of the bb' domains of protein disulfide isomerase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: p4hb, erba2l, pdi, pdia1, po4db. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (200 residues)