_EC 5.3.2.1 Phenylpyruvate tautomerase. 50 PDB entries  
EC 5.-.-.- Isomerases. [2,321 PDB entries]
EC 5.3.-.- Intramolecular oxidoreductases. [880 PDB entries]
EC 5.3.2.- Interconverting keto- and enol- groups. [68 PDB entries]
EC 5.3.2.1 Phenylpyruvate tautomerase. [50 PDB entries]    
1ca7

Reaction: Keto-phenylpyruvate = enol-phenylpyruvate.
 


Keto-phenylpyruvate
=
enol-phenylpyruvate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Phenylpyruvate keto--enol tautomerase. Phenylpyruvic keto--enol isomerase.
Comments: Also acts on other arylpyruvates.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 50 PDB entries in enzyme class E.C.5.3.2.1

  PDB code Protein
1ca7
Macrophage migration inhibitory factor (mif) with hydroxphenylpyruvate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group ENO is 92.00% similar to enzyme reactant phenylpyruvate
1cgq
Macrophage migration inhibitory factor (mif) with alanine inserted between pro-1 and met-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21(de3). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (115 residues) CATH domain: 3.30.429.10
1fim
Macrophage migration inhibitory factor
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: liver. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: methionine auxotropic escherichia coli strains harvested in a medium containing selenomethionine
Chain: A (103 residues) CATH domain: 3.30.429.10
1gcz
Macrophage migration inhibitory factor (mif) complexed with inhibitor.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (118 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group YZ9 is 61.00% similar to enzyme reactant phenylpyruvate
1gd0
Human macrophage migration inhibitory factor (mif)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (118 residues) CATH domain: 3.30.429.10
1gif
Human glycosylation-inhibiting factor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (115 residues) CATH domain: 3.30.429.10
1hfo
The structure of the macrophage migration inhibitory factor from trichinella spiralis.
Source: Trichinella spiralis. Trichina. Organism_taxid: 6334. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: jm109
Chains: A, B, C, D, E, F (113 residues) CATH domain: 3.30.429.10
1ljt
Crystal structure of macrophage migration inhibitory factor complexed with (s,r)-3-(4-hydroxyphenyl)-4,5-dihydro-5- isoxazole-acetic acid methyl ester (iso-1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group HDI is 61.00% similar to enzyme reactant phenylpyruvate
1mff
Macrophage migration inhibitory factor y95f mutant
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
1mfi
Crystal structure of macrophage migration inhibitory factor complexed with (e)-2-fluoro-p-hydroxycinnamate
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group FHC is 78.00% similar to enzyme reactant phenylpyruvate
1mif
Macrophage migration inhibitory factor (mif)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
1p1g
Macrophage migration inhibitory factor (mif) with pro-1 mutated to gly-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21(de3). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
1uiz
Crystal structure of macrophage migration inhibitory factor from xenopus laevis.
Source: Xenopus laevis. African clawed frog. Organism_taxid: 8355. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (115 residues) CATH domain: 3.30.429.10
1uz7
Comparative homology modeling of brugia malayi macrophage migration inhibitory factor
Source: Brugia malayi. Filarial nematode worm. Strain: trw. Organ: lymph node. Tissue: lymphoid
Chains: A, B, C (114 residues)
2gdg
Crystal structure of covalently modified macrophage inhibitory factor
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: mif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
2ooh
Crystal structure of mif bound to a novel inhibitor, oxim-11
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mif. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group OX3 is 42.86% similar to enzyme reactant phenylpyruvate
2oow
Mif bound to a fluorinated oxim derivative
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mif. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group OX4 is 40.91% similar to enzyme reactant phenylpyruvate
2ooz
Macrophage migration inhibitory factor (mif) complexed with oxim derivative not containing a ring in its r-group)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mif. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group OX5 is 57.14% similar to enzyme reactant phenylpyruvate
3b9s
Macrophage migration inhibitory factor (mif) complexed with 4-ipp.
Source: Homo sapiens. Expressed in: escherichia coli.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group RW1 is 60.00% similar to enzyme reactant phenylpyruvate
3ce4
Structure of macrophage migration inhibitory factor covalent inhibited by pmsf treatment
Source: Homo sapiens. Human. Gene: mif, glif, mmif. Expressed in: escherichia coli.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group PMS is 46.67% similar to enzyme reactant phenylpyruvate
3djh
Macrophage migration inhibitory factor (mif) at 1.25 a resol
Source: Homo sapiens. Organism_taxid: 9606. Gene: mif, glif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
3dji
Crystal structure of macrophage migration inhibitory factor an acetaminophen dimer derived from napqi
Source: Homo sapiens. Organism_taxid: 9606. Gene: mif, glif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group 3E1 is 41.67% similar to enzyme reactant phenylpyruvate
3hof
Structure of macrophage migration inhibitory factor (mif) wi acid at 1.9a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (118 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group DHC is 78.57% similar to enzyme reactant phenylpyruvate
3ijg
Macrophage migration inhibitory factor (mif) bound to the (r stereoisomer of av1013
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group AVR is 45.00% similar to enzyme reactant phenylpyruvate
3ijj
Ternary complex of macrophage migration inhibitory factor (m both to 4-hydroxyphenylpyruvate and to the allosteric inhib av1013 (r-stereoisomer)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group EN1 is 92.00% similar to enzyme reactant phenylpyruvate
3jsf
Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (115 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group XV1 is 47.00% similar to enzyme reactant phenylpyruvate
3jsg
Crystal structure of macrophage migration inhibitory factor hydroxyquinoline inhibitor 707 at 1.58a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (118 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group 0IN is 50.00% similar to enzyme reactant phenylpyruvate
3jtu
Crystal structure of macrophage migration inhibitory factor hydroxyquinoline inhibitor 708 at 1.86a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (118 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group ZIN is 50.00% similar to enzyme reactant phenylpyruvate
3l5p
Crystal structure of macrophage migration inhibitory factor (mif) with imidazopyridazinol inhibitor at 1.80a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
3l5r
Crystal structure of macrophage migration inhibitory factor (mif) with phenylchromenone inhibitor at 1.94a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group 47X is 52.00% similar to enzyme reactant phenylpyruvate
3l5s
Crystal structure of macrophage migration inhibitory factor (mif) with imidazopyrimidinylphenyl inhibitor at 1.86a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
3l5t
Crystal structure of macrophage migration inhibitory factor (mif) with thiophenepiperazinylquinolinone inhibitor at 1.86a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
3l5u
Crystal structure of macrophage migration inhibitory factor (mif) with benzothiazole inhibitor at 1.90a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (116 residues) CATH domain: 3.30.429.10
3l5v
Crystal structure of macrophage migration inhibitory factor (mif) with glycerol at 1.70a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (117 residues) CATH domain: 3.30.429.10
3smb
Phenethylisothiocyanate covalently bound to macrophage migra inhibitory factor (mif)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group LE2 is 53.33% similar to enzyme reactant phenylpyruvate
3smc
Macrophage migration inhibitory factor (mif) with covalently sulforaphane
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
3u18
Chicago sky blue 6b, a novel inhibitor for macrophage migrat inhibitory factor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mif, glif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
3wnt
Multiple binding modes of benzyl isothiocyanate inhibitor co with macrophage migration inhibitory factor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
4etg
Crystal structure of mif l46g mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mif, glif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
4eui
Crystal structure of mif l46f mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mif, glif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
4evg
Crystal structure of mif l46a mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mif, glif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
4f2k
Macrophage migration inhibitory factor covalently complexed phenethylisothiocyanate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group LE2 is 53.33% similar to enzyme reactant phenylpyruvate
4grn
Crystal structure of paam mutant of human mif
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: glif, human, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (116 residues) CATH domain: 3.30.429.10
4gro
Crystallographic and biological characterization of n- and c mutants of human mif
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (117 residues) CATH domain: 3.30.429.10
4grp
Crystallographic and biological characterization of n- and c mutants of human mif
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (118 residues) CATH domain: 3.30.429.10
4grq
Characterization of n- and c- terminus mutants of human mif
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (116 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group AVL is 45.00% similar to enzyme reactant phenylpyruvate
4grr
Characterization of n- and c- terminus mutants of human mif
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (116 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group AVR is 45.00% similar to enzyme reactant phenylpyruvate
4gru
Crystallographic and biological characterization of n- and c mutants of human mif
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: glif, mif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
4gum
Cystal structure of locked-trimer of human mif
Source: Macaca mulatta. Rhesus macaque,rhesus macaques,rhesus monk organism_taxid: 9544. Strain: human. Gene: mif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H, I (114 residues) CATH domain: 3.30.429.10
4oyq
(6-isothiocyanatohexyl)benzene inhibitor complexed with macr migration inhibitory factor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mif, glif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (114 residues) CATH domain: 3.30.429.10
Bound ligand:   Het Group 1X2 is 50.00% similar to enzyme reactant phenylpyruvate